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The Universal Grinder for Every Application
Thanks to its special mode of operation, the Fritsch Mortar Grinder PULVERISETTE 2 is the ideal universal grinder in the laboratory – for analysis, quality control and materials testing as well as for the mixing and homogenisation of pastes and creams on a laboratory scale. Its particularly gentle grinding by friction with almost no thermal load is ideal for the preparation of tablets in galenics. Using liquid nitrogen it also grinds difficult-to-mill samples with moist, fibrous or elastic structures. The PULVERISETTE 2 is also ideally suited for mixing of solids or liquids and solids. With brief, reliably reproducible grinding and mixing times, it is loss and dust free. It is capable of producing final finenesses of between 10 and 20µm, with a feed size of 6 – 8mm and a maximum sample quantity of up to 190ml.
Well-conceived details for efficient working and quick cleaning: the mortar bowl and pestle of the PULVERISETTE 2 lock in place securely thanks to their bayonet clamping with just one motion and are just as quickly removed for cleaning. The pestle pressure can also be easily adjusted during grinding. The special Fritsch scraper kinematics ensure that the scraper can be fine-tuned in height and depth and that the setting angle to the mortar bowl can be adjusted according to your material and application – all conveniently from the outside.
The PULVERISETTE 2 is ideally suited for cryogenic grinding, where the material to be ground is embrittled with the addition of liquid nitrogen. In this manner moist, fibrous or elastic samples such as tomatoes, rubber, synthetic resins or plants can be ground without problem in the stainless steel grinding set.
Mortar bowls and pestles for the PULVERISETTE 2 are available in 7 different materials for contamination-free sample grinding -– for each application the suitable one and the best protection against undesired contamination!
MORE INFO. 136
New Drug Discovery Company Created to Progress Retinoic Acid Receptor Alpha Agonist for Alzheimer’s Disease
King’s College London, The Wellcome Trust and Advent Venture Partners today announced the formation of a new UK biotechnology company, CoCo Therapeutics Ltd, to progress the research of Professor Jonathan Corcoran into the development of new treatments for Alzheimer’s disease.
The company builds on the success of research funded through the Wellcome Trust’s Seeding Drug Discovery initiative investigating the role of the retinoic acid receptor, RAR-alpha, and molecules that act on it in Alzheimer’s disease.
The Neuroscience Drug Discovery Unit at King’s, led by Professor Corcoran, has been optimising compounds for treatment of CNS disorders since 2008. The group has previously shown that molecules that act on RAR-alpha can affect multiple parts of the Alzheimer’s disease pathway and therefore have the potential to produce an effective therapy that would otherwise need several points of intervention from different drugs. CoCo Therapeutics Ltd will now take forward the lead compound into late-stage preclinical studies and clinical trials, which is the next step towards assessing whether the approach has any therapeutic benefit in patients.
Funding to launch and progress CoCo Therapeutics has been provided by Advent Venture Partners, one of Europe's most successful venture capital investors in market-leading technology and life sciences businesses. Dr Raj Parekh, General Partner at Advent, will be the Founding Chairman of the new company.
Professor Jonathan Corcoran, Director of the Neuroscience Drug Discovery Unit at King’s College London, said: “I am delighted to be working with Advent on this project. Our research has shown early promise in this area and this partnership will enable us to progress the work further. This is an exciting step forward in the search for effective Alzheimer's disease treatments.”
Alzheimer’s disease (AD) is the most common cause of dementia, affecting around 5.3 million people in the US, 417,000 people in the UK and many millions of others worldwide. It is estimated that this incidence will more than double by 2050, should current trends continue.
MORE INFO. 137
FRITSCH · ANALYSETTE 22
DETERMINATION OF PARTICLE SIZES. SIMPLE AND FLEXIBLE.
LE. June 04 – 07, 2013
Hall 3 • Booth A10-B11 Paris Expo – Porte de Versailles
Two models for all applications: wo models for all applications:
• Extra large measuring range 0.01 – 2000 µm • Ideal for dry and wet measurement of particle sizes • Modular system of measuring unit and dispersion units • Practical fast-switch-system and short measuring times • Simplest operation – open confi guration of the measuring process
ANALYSETTE 22 MicroTec plus – Measuring range 0.08 – 2000 µm ANALYSETTE 22 NanoTec plus – Measuring range 0.01 – 2000 µm
Quality and technology made in Germany: the ANALYSETTE 22 MicroTec plus compact all-round-laser for all applications – and the
ANALYSETTE 22 NanoTec plus for perfect results down to the nano range. Info and sample analysis:
www.fritsch-sizing.com
Or give us a call and get a personal consultation! +49 67 84 70 138 ·
crolly@fritsch.de
FRITSCH. ONE STEP AHEAD. FRITSCH GMBH · MILLING AND SIZING · INDUSTRIESTRASSE 8 · 55743 IDAR-OBERSTEIN · GERMANY · PHONE +49 67 84 70 0 ·
INFO@FRITSCH.DE ·
WWW.FRITSCH.DE
MORE INFO. 138
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