Agilent Mass Spectrometry Superior performance and productivity for all your applications
Whether you’re screening for multiple pesticide residues, discovering low abundance biomarkers, quantifying trace drug metabolites, or monitoring elemental contaminants in soil and water, Agilent mass spectrometry can improve the quality - and the confidence - of your results. And with today’s most complete selection of integrated MS workflow solutions, we can also increase your lab’s productivity and lower your analysis costs.
APRIL 2013 - VOLUME 38 ISSUE 3
ATTAIN SUPERIOR
MASS SPEC PERFORMANCE
Confi dence means attaining superior analytical performance, attaining 24/7 reliability, maximum uptime and productivity—everything you expect from the leader in mass spectrometry. Across your MS platforms, Agilent provides one single, consistent user interface. After 40+ years of innovation and expansive experience with the industry’s largest installed base, Agilent’s best-in-class portfolio continues to push the boundaries of MS technology, delivering market-leading solutions.
Learn more about Agilent Mass Spec technology at:
www.agilent.com/chem/MSPerformance
GC/MS—Advanced separation capabilities, exclusive Capillary Flow Technology, powerful automation and easy-to-use software let you get more done in less time, at the lowest possible cost per sample. A full range of GC/MS analysis techniques —including single quadrupole, triple quadrupole, and ion trap—let you exactly match your system to the needs of your application, and to your lab’s budget.
LC/MS—For non-targeted or unknown contaminants such as pesticides, Agilent Accurate-Mass TOF and Q-TOF MS systems combine best-in-class performance with legendary Agilent reliability. And for highly selective, sensitive detection and quantification of targeted compounds, the new Agilent 6490 Triple Quadrupole LC/MS, with Agilent iFunnel technology, delivers breakthrough zeptomole sensitivity, the broadest linear dynamic range—all in an extremely compact desktop footprint.
Scan the QR code for more information © Agilent Technologies, Inc. 2012
about Agilent’s LC/MS, GC/MS, ICP-MS and MassHunter Software
MORE INFO. 1 Labmate: The Laboratory World at Your Fingertips
ICP-MS—Agilent’s industry-leading ICP-MS technology gives you the flexibility to analyse even the toughest, dirtiest samples with superior sensitivity. Offering unmatched matrix tolerance and ability to remove interferences, you can rapidly screen, confirm, and quantify target compounds in a single injection—without the need to run external standards.
Explore Agilent’s mass spectrometry solutions today.
www.agilent.com/chem/MSPerformance
MORE INFO. 1 Mass Spectrometry & Spectroscopy Fanny Fu & André Schreiber 14-19
LC-MS/MS Analysis of Emerging Food Contaminants Quantitation and Identification of Dicyandiamide in Milk and Other Protein-Rich Foods
14
Head Office - International Labmate Ltd Oak Court, Sandridge Park, St AIbans, Hertfordshire AL3 6PH, United Kingdom. Tel: +44 (0)1727 855574 • Fax: +44 (0)1727 841694 Email:
info@intlabmate.com •
sales@intlabmate.com ISSN 0143-5140
Publishers of: International Labmate, Labmate UK & Ireland, Lab Asia, Chromatography Today, International Environmental Technology, Asian Environmental Technology, Pollution Solutions, Petro Industry News and Measurement Analysis China
Laboratory Products
Research & Events News Heather Hobbs
3
News & Views Heather Hobbs
20 Publisher Michael H. Pattison
Director of Publications Marcus Pattison
michael@intlabmate.com
marcus@intlabmate.com
North American Area Manager Carol Hardy
Director, Asia Pacific Marie Izzard
carol@intlabmate.com
marie@intlabmate.com.au
Sales & Marketing Manager Chris Jarvis
Area Managers John Hobbs-Morris Carly Hider
Classified Sales Silvi Sutherland
Online Manager Rob Parker
Guide Manager Sam Jackson
Guide Assistant Joanna Hemmings
Reader Services Manager Sue Petts
chris@intlabmate.com
john@intlabmate.com
carly@intlabmate.com
silvi@intlabmate.com
rob@intlabmate.com
sam@intlabmate.com
joanna@intlabmate.com
sue@intlabmate.com Editor Gwyneth Astles
Contributing Editor Heather Hobbs
gwyneth@intlabmate.com
heather@intlabmate.com
Contributing Editor - Separation Science Bernie Monaghan
bernie@intlabmate.com
Print Production & Procurement Manager Gary Durham
Production Manager Robert Battell
Production Team Heather Vincent Jill Mitchell Caroline Belt
Finance Controller Chris Brown
Accounts Assistants Linda Hudson
Maureen Woodhouse
Credit Control Patricia Rogers
Subscriptions Manager Maureen Woodhouse
Market Research
gary@intlabmate.com
robert@intlabmate.com
heatherv@intlabmate.com
jill@intlabmate.com
caroline@intlabmate.com
chris@labmate.net
linda@labmate.net
maureen@labmate.net
patricia@labmate.net
maureen@labmate.net Marstonbury Ltd
Refractometry & Polarimetry Gwyneth Astles
34
Drug Discovery & Pharmaceuticals Gwyneth Astles
Printed by Warners Midlands Plc, Covers printed by Colt Press Ltd, Published by International Labmate Ltd
Published: January, February, April, May Buyers Guide, July, August, October International Labmate is distributed to scientists, technologists, laboratory technicians and environmentalists throughout the Europe and Middle East, free of charge. The publication has the support of leading suppliers of equipment in the region and is displayed at the major exhibitions and conferences in these markets to attract additional readership.
Subscriptions: FOR ONE YEAR; Outside Europe or the Middle East - $100. Cheques made payable to International Labmate Ltd Alternatively fill in the Buying Now/User card and tick the subscription box
In order to obtain information on any of the products included in this journal, please fill in the appropriate numbers on the Reader Reply card and post or fax it to us. Alternatively contact the company directly by email, phone or via the website.
Buying Now Scientific Instruments Survey: Should you use or be planning to buy scientific apparatus and would like to receive the latest available information, please return the appropriate card.
North American Office: Carol Hardy - International Labmate Ltd 6635 West Happy Valley Road, Suite 104, #505, Glendale, AZ 85310, United States Tel: +(1) 623-869-0184 Fax: +(1) 623-321-9200 E-mail:
carol@intlabmate.com
Asian Office: Marie Izzard - International Labmate Ltd PO Box 374, Mona Vale, NSW, 1660, Australia Tel: +61 (0) 2 9918-0317 Fax: +61 (0) 2 9918-0316 E-mail:
marie@intlabmate.com.au
Japan: Mr Koichi Ogawa - OTO Research Corporation Takeuchi Building 1 -34-12 Takatanobaba, Shinjuku-Ku, Tokyo 169, Japan Tel: (03) 3208 7821 Fax: (03) 3200 2889
Korea: Dong-Shik Chai, Dong-Myung Communications Inc 191-1. Pyungchang-Dong, Chongno-Ku , Seoul, 110-012 Korea Tel: 82 2 391 4254 Fax: 82 2 391 4255
Microscopy & Microtechnology Sophia Kenrick
International Labmate is published six times per annum in tabloid format. In addition a most comprehensive "Guide to Laboratory and Environmental Equipment" printed in A4 format. It incorporates companies, products and dealers, mailed in May/June.
Although every effort is made to ensure the accuracy of material published, International Labmate and its offices cannot accept responsibility for claims made by contributors, manufacturers or advertisers.
© All rights reserved by International Labmate Ltd. Reproduction in part or whole without written permission is strictly prohibited. Please look after the environment by recycling this magazine
Microscopy News Heather Hobbs
60 58-60
Probing the Interactions Among Three Proteins to Evaluate Whether an Antibody and Inhibitor Compete for the Same Binding Site on an Enzyme
58 42
Safety, Hazard Containment & Sterilising Equipment Gwyneth Astles
54 Special Features
Business Opportunities Asia Heather Hobbs
56
96- and 384-Channel Electronic Pipettes An Affordable Way to Increase Pipetting Productivity
Michael Beier 50
Pittcon Show Review Heather Hobbs
22
At the time of this issue going to press, International Labmate received the sad news that Bernie Monaghan, our contributing Editor for Separation Science, passed away on Saturday, 6 April.
A full obituary will appear in the next issue.
In this Issue Chromatography
Chromatography Modelling in High Performance Liquid Chromatography Method Development
Imre Molnár, Hans-Jürgen Rieger & Róbert Kormány 4
4-13
T r
u
o
Y
b
u
a e o
L
h J
l
.
r
a
o
o
n N
r
o o
t
F 1
a
y
r r
COVER STORY
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48 |
Page 49 |
Page 50 |
Page 51 |
Page 52 |
Page 53 |
Page 54 |
Page 55 |
Page 56 |
Page 57 |
Page 58 |
Page 59 |
Page 60 |
Page 61 |
Page 62 |
Page 63 |
Page 64 |
Page 65 |
Page 66 |
Page 67 |
Page 68
