search.noResults

search.searching

dataCollection.invalidEmail
note.createNoteMessage

search.noResults

search.searching

orderForm.title

orderForm.productCode
orderForm.description
orderForm.quantity
orderForm.itemPrice
orderForm.price
orderForm.totalPrice
orderForm.deliveryDetails.billingAddress
orderForm.deliveryDetails.deliveryAddress
orderForm.noItems
thymol and carvacrol on intestinal integrity and gut barrier function. The stability of the tight junctions (a unique connection between cells), for example is linked to the amount of occludin, which increases the physical barrier function of the intestine. Under challenge conditions and during inflammation processes, occludin is known to be downregulated. A broiler study with C. perfringens challenge showed lower levels of occludin, which increased with the addition of the protected thymol and carvacrol. This lowers the risk of pathogen translocation, or the uncontrolled transfer of different molecules from the lumen into the bloodstream. It has also been shown that broilers receiving the additive under Eimeria or C. perfringens challenges showed significantly lower serum endotoxin levels, indicating improved mucosal barrier integrity. Adding the protected essential oil blend to the ration has also shown increased villus height to crypt depth ratio, another well recognised marker for intestinal health. Macroscopic intestinal lesions are another relevant indicator of gut health. In Eimeria and C. perfringens challenge studies, these lesions were significantly reduced with NE150. Fewer intestinal lesions can result in a lower inflammation processes and can directly translate to performance improvements. During a host-pathogenic infection, pro-inflammatory cytokines are released to activate the immune system. However, the inflammation needs to be controlled as a prolonged and persistent activation of pro-inflammatory cytokines can result in mucosal damage as well as impact the stability of tight junctions. The inflammation also consumes a lot of energy, which impacts performance. The premixture is shown to downregulate pro-inflammatory cytokines, which helps to protect intestinal barrier function and save energy. Conclusively, protected thymol and carvacrol lower the risk of


Figure 2 - Improved antioxidant status. Control NE150 60 g/mt NE150 100 g/mt NE150 200 g/mt


160 170 180 190 200


110 120 130 140 150


100 SOD Serum 24 d GSH-Px SOD Serum 42 d GSH-Px Linear P = 0.002 Linear P = 0.026 Linear P = 0.004 Linear P = 0.017


4.5 5.0 5.5 6.0 6.5


100 MDA Serum 24 d MDA Serum 42 d ▶ GUT HEALTH | DECEMBER 2020 73


7.0 7.5 8.0


Linear P = 0.003


performance depression and intestinal damage caused by inflammation. Thymol and carvacrol are also known to have anti-oxidative capacities due to their chemical structure. To understand how the additive could benefit broilers’ oxidative status, a study was done measuring various biomarkers, such as super oxide dismutase (SOD) and glutathione peroxidase (GSH-Px). These enzymes are responsible for the conversion of reactive oxygen species (ROS) to harmless substances. ROS are a result of normal metabolism but are toxic to the organism and increase significantly during an infection or stress. It was shown that both enzymes increased (Figure 2) when the additive was added to the diet. As a result, the malondialdehyde levels, a marker for lipid peroxidation, were significantly reduced in broilers. The essential oil product can therefore, directly and indirectly, help to maintain a balance between ROS and the defence system, which lowers the risk of tissue and cell damage as well as performance losses.


Consistent performance improvement With its broad impact on gut health it is not surprising that broilers receiving the additive show a consistent improvement in feed conversion ratio with an average of 3.7% when used at the recommended dosage rate of 30-60 g/t. In addition, the essential oil blend can be used in feeding programmes to support the birds under coccidiosis, necrotic enteritis or gut health challenges to help alleviate negative effects on the animals. This array of trials show that producers can use Next Enhance 150 in their strategy to improve feed conversion ratio, thereby reducing production cost efficiently and increasing the profitability of commercial broiler productions.


References available upon request


U/ml


mmol/ml


Page 1  |  Page 2  |  Page 3  |  Page 4  |  Page 5  |  Page 6  |  Page 7  |  Page 8  |  Page 9  |  Page 10  |  Page 11  |  Page 12  |  Page 13  |  Page 14  |  Page 15  |  Page 16  |  Page 17  |  Page 18  |  Page 19  |  Page 20  |  Page 21  |  Page 22  |  Page 23  |  Page 24  |  Page 25  |  Page 26  |  Page 27  |  Page 28  |  Page 29  |  Page 30  |  Page 31  |  Page 32  |  Page 33  |  Page 34  |  Page 35  |  Page 36  |  Page 37  |  Page 38  |  Page 39  |  Page 40  |  Page 41  |  Page 42  |  Page 43  |  Page 44  |  Page 45  |  Page 46  |  Page 47  |  Page 48  |  Page 49  |  Page 50  |  Page 51  |  Page 52  |  Page 53  |  Page 54  |  Page 55  |  Page 56  |  Page 57  |  Page 58  |  Page 59  |  Page 60  |  Page 61  |  Page 62  |  Page 63  |  Page 64  |  Page 65  |  Page 66  |  Page 67  |  Page 68  |  Page 69  |  Page 70  |  Page 71  |  Page 72  |  Page 73  |  Page 74  |  Page 75  |  Page 76  |  Page 77  |  Page 78  |  Page 79  |  Page 80  |  Page 81  |  Page 82  |  Page 83  |  Page 84  |  Page 85  |  Page 86  |  Page 87  |  Page 88  |  Page 89  |  Page 90  |  Page 91  |  Page 92  |  Page 93  |  Page 94  |  Page 95  |  Page 96  |  Page 97  |  Page 98  |  Page 99  |  Page 100  |  Page 101  |  Page 102  |  Page 103  |  Page 104  |  Page 105  |  Page 106  |  Page 107  |  Page 108  |  Page 109  |  Page 110  |  Page 111  |  Page 112  |  Page 113  |  Page 114  |  Page 115  |  Page 116  |  Page 117  |  Page 118  |  Page 119  |  Page 120  |  Page 121  |  Page 122  |  Page 123  |  Page 124