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Prevent intestinal inflammation to ensure piglet performance


Intestinal inflammation can impair the absorption of nutrients and up to 30% of the energy ingested is used to manage this process instead of contributing to performance. Plant extracts can help both sows and piglets taking care of intestinal inflammation.


BY FABIEN GUILLARD, INTERNATIONAL SWINE MARKET MANAGER, WISIUM T


he intestine constitutes the largest interface be- tween the animal and its environment. An intact in- testinal barrier is thus essential in maintaining gut health and preventing tissue injury and several dis-


eases. The intestinal barrier is formed by enterocyte mem- branes, tight junctions, secreted mucus, and immunologic fac- tors. Dysfunction of this barrier can be caused by different types of stress and can lead to increased intestinal permeability.


Sow and piglet challenges Weaning is well-known as the critical period for piglets where they face multi-factorial stresses and challenges in a short time: • Adaptation to the feed intake – The longer the time without eating at weaning, the higher the risk of diarrhoea. Effectively, that drop in feed intake is likely to cause diffi- culties to meet nutritional requirements due to reduction of the villi height, thus nutrient absorption area;


• Adaptation to the feed – from milk to a solid feed; • Feed composition changes – from milk containing lac- tose to a pre-starter feed containing mainly or exclusively plant-based raw-materials;


• Adaptation to a new environment – separation from the sow to litter, from farrowing crate to post-weaning pen, with possible variation of the microbiota present in the environment.


Farrowing and lactation remain two critical periods for sows. During these periods, there is a high risk of inflammatory re- action and oxidative stress. The most visible impact of the


Table 1- Results of the in vitro research. No inflammatory challenge


Negative control TEER (mOhm/cm²)


Basal IL 8 secretion (pg/mL) a, b, c with P< 0.05


54


343.7a 13.73a


Positive control


241.1b 609.8b


Extract 1 Alkaloids 262.1b 613.0b


inflammatory process for sows is the milk quantity and quali- ty. Sows with intestinal inflammation and oxidative stress dedicate less energy for milk production, which can impacts piglet growth. Recent research explains up to 30% of the in- gested energy is deviated to manage these processes.


Inflammation and plant extracts Active ingredients from plant extracts appear to offer a solution. Wisium’s R&D department has been working on a selection of plant extracts combinations, known from centuries in the traditional Asian pharmacopeia for having individual anti-inflammatory, anti-oxidant and analgesic properties. The most powerful combination was selected thanks to its synergistic effects to create the patented product Powerjet, made of a plant from the alkaloid family and a second one from neo-lignans. The benefits of using a combination of plant extracts has been demonstrated through in vitro research and confirmed by in vivo studies.


In vitro research A university trial was conducted in Beauvais, France, in order to assess the synergistic impact of the plant extracts on both in- testinal integrity and inflammatory process. Human colon cells were cultivated and then stimulated with a severe model of in- flammation (cytokines cocktail). The plant extracts have been tested alone or in combination to evaluate their impact on Trans-Epithelial Electric Resistance (TEER) and Interleukins 8 se- cretion (IL-8). The TEER measurement allows to assess the barri- er function of epithelial cells. A high TEER value is an indicator of well-preserved tight junctions. IL-8 are pro-inflammatory


WITH inflammatory challenge (cytokines cocktail) Extracts 2 + 3 Neo lignans 265.7b 520.9b


Powerjet


(Alkaloids + Neolignans) 304.4c 429.7c


▶ GUT HEALTH | DECEMBER 2020


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