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How thymol and carvacrol influence gut health


Poultry trials challenged with Eimeria and Clostridium perfringens showed that an encapsulated, highly concentrated blend of thymol with carvacrol promotes healthy intestinal microbial flora, as well as supports gut barrier function, inflammation processes and immunity.


BY SVEN KELLER, SR TECHNICAL SERVICES MANAGER-GUT HEALTH FOR NOVUS EMEA T


0.00 0.20 0.40 0.60 0.80 1.00 1.20 1.40


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he industry has made huge efforts in recent years to develop solutions focusing on gut health. This is not only due to a direct link to improved feed efficiency and profitability, animal welfare or food safety, but


also due to changes in consumer preferences and regulatory requirements. When it comes to poultry gut health, coccidio- sis and necrotic enteritis are major economic challenges, par- ticularly when present in a subclinical form where symptoms may not be observable. Due to epithelial damage and inflam- mation, these subclinical infections reduce feed efficiency and result in an opportunity for potential pathogens.


Coated essential oil blend Where essential oils are concerned, thymol and carvacrol are scientifically well-documented compounds. Due to their phe- nolic structure (having a cyclic ring with a hydroxyl group at- tached), they are recognised as efficient compounds showing a variety of beneficial effects in the gut. Next Enhance 150


Caecal C. Perfringens d22 (%)


feed additive (NE150) is a highly concentrated blend contain- ing thymol and carvacrol protected by a unique coating. This ensures that the active ingredients are stable during pelleting and can ultimately result in a controlled release to the lower parts of the intestinal tract.


Multi-faceted approach Thymol and carvacrol are highly effective against a wide range of potential pathogens. In a variety of studies, NE150 has demonstrated its potential to establish a healthy microbi- al composition by promoting higher lactic acid-producing bacteria and reduce pathogenic species. An example of the antimicrobial effects in broilers is shown in Figure 1. In one study, an Eimeria challenge model was used, which typically increases the levels of C. perfringens. It is well known that C. perfringens is the causative agent for necrotic enteritis but requires other predisposing factors to become clinical or subclinical. The invasion of intestinal cells by the Eimeria parasite is seen as the major predisposing factor because it creates tissue damage and leakage of plasma proteins used by C. perfringens. Broilers receiving the protected essential oils showed lower levels of C. perfringens as well as lower levels of Enterobacteriaceae, a large family of pathogens including E. Coli or Salmonella. As a result, the essential oil product is shown to lower the risk of a bacterial overgrowth, which is key in the development of necrotic enteritis.


Biomarkers can be used to study the effect of protected


Figure 1 - Reduction in caecal C. perfringens & Enterobacteriaceae 8 days post-challenge with Eimeria. Caecal Enterobacteriaceae d22 (%)


0.25 a


Control NE150 15 g/mt NE150 30 g/mt P = 0.038


a 0.20 P = 0.035 0.15 0.10 b b 0.05 0.00 ▶ GUT HEALTH | DECEMBER 2020


Control NE150 15 g/mt NE150 30 g/mt


ab b


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