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pressure, triggered by swine-specific pathogenic germs, is one of the main reasons for using antibiotic medications. Many in vitro studies displayed pronounced antibacterial ef- fects following the use of fatty acids against both Gram-nega- tive and Gram-positive germs. Lauric acid and glycerol monolaurate are considered to be particularly active antibac- terial ingredients. The antimicrobial potential of MCFAs de- scribed in literature has already been applied in practice.


Reinforce immunity Many different additives are already being used in pig feed- ing. Here it is important to reinforce the immunity of the ani- mals and to reduce at the same time the use of antibiotics. The fields of application and the effect of the respective acids vary widely, however, synergistic effects can be created by targeted selection and with the combination of acids and other phytogenic substances. The influence of different fatty acids on the development of swine-specific pathogenic germs was examined in an in vitro study. The objective of this study was to use the results to identify the most efficient combination of active ingredients that effectively inhibit bacterial growth. The antibacterial activity of the MCFAs caprylic acid (C8), capric acid (C10), C12 and myristic acid (C14), respectively the combination of different MCFAs, was examined towards various Gram- positive and Gram-negative bacteria. Additionally, the matrix encapsulated combination product, Bewi-Fatrix SynerG+, which is based on Lauric acid, monoglycerides of short-chain fatty acids and plant extracts, and of two further combination products (1 and 2) were investigated on the growth of E. coli, S. suis, Salmonella poona (S. poona) and C. perfringens. The different bacterial strains were incubated in the presence of different concentrations of the mentioned active ingredients in a nutrient medium. Over a 15-hour period the bacterial growth was measured photometrically every hour through the absorption at a wavelength of 600nm. The results were evaluated via the data of the minimal inhibitory concentration 50 (MIC50


).


Results of in vitro study Lauric acid shows the greatest influence on bacterial growth. Particular for Gram-positive bacteria such as S. suis and C. per- fringens the active ingredients in Bewi-Fatrix SynerG+ exhibit a distinct influence. Bacterial growth declines with increasing concentration of these active ingredients. In comparison with the two combination products 1 and 2, it became apparent that the addition of the product to the nutrient medium in- hibits the growth of Gram-positive germs by 50% already at lower concentrations. Just 0.1% of the product is sufficient to reduce the bacterial growth of S. suis and C. perfringens by 50%. Furthermore, an influence of Bewital agri’s product on the growth of E. coli and S. poona can also be observed. Only 0.4%, respectively 0.6% of the product is sufficient in order to


achieve MIC50 (Table 1). It was established that various con-


centrations of the antimicrobial active agents C12, C14, fatty acid mix C8/C10 and glycerol monolaurate influenced the in vitro growth of swine-specific pathogenic germs. Further- more, the combination products 1 and 2 also displayed an antimicrobial effect with certain concentrations. However, neither combination product showed any uniform improve- ment by comparison with the individual active agents. Only the combination product Bewi-Fatrix SynerG+ showed a bet- ter effect here. It is evident from the in vitro analysis that the product innovation is the most effective available combina- tion against Gram-positive bacteria. Initial feeding tests con- ducted on German, Spanish and Italian farms with confirmed S. suis infection showed that the use of the product as a feed additive lead to a considerable reduction in the use of medi- cation. The risk of infections is reduced, and performance of the animals is positively influenced. The farm managers re- ported more vital piglets and improved piglet growth.


A healthy gut is essential to a healthy piglet. By matrix encapsulation active ingredients reach the gut exactly where they are needed.


Table 1- Minimal concentration of tested agents to reduce bacterial growth by 50% in vitro.


MIC50 in %


C8C10 (60:40) Lauric acid (C12) Myristic acid (C14)


Escherichia Streptococcus coli


suis


0.3% 0.2% 0.2%


Glycerol monolaurate (GML) 0.4% Bewi-Fatrix SynerG+ Combination product 1 Combination product 2


0.4%


>0.6% 0.5%


<0.2% 0.2% 0.2% 0.1% 0.1%


>0.6% 0.6%


Salmonella poona >1.0% 0.2%


0.4-0.8% 0.6% 0.6%


>0.6% >0.6%


▶ GUT HEALTH | DECEMBER 2020


Clostridium perfringens 0.1% 0.1% 0.3% 0.1% 0.1% 0.2% 0.2%


111


PHOTO: BEWITAL


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