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Mitigating chronic gut inflammation in animal production


Inflammation is a complicated physiological process in response to various immune stimuli. This physiological reaction can become detrimental when the response is prolonged and dysregulated called “chronic inflammation”. A notable feature of chronic inflammation is its high energetic cost.


BY ALIREZA KHADEM, RESEARCH AND TECHNICAL MANAGER POULTRY, INNOVAD I


t is well established that the chronic (low-grade) inflammatory response in the intestine, results in the disruption of digestive function, nutritional malabsorption, and consequently growth retardation.


Research has demonstrated that pro-inflammatory pathways promote muscle catabolism to supply amino acids and energy substrates for immune responses. These shifts in systemic metabolism may also explain the detrimental effects


Figure 1A - Regression analysis of the intestinal   


Day 28 400 10


on performance and carcass traits commonly associated with chronic inflammation which results in economic losses.


Real conditions A holistic approach that demonstrates several, complementary modes of action is necessary for overall protection against chronic inflammation. In our re- search, first, we established successfully, a ‘chicken chronic gut inflammation model’ under real production conditions.


Figure 1B - Analysis of Linear regression of the intestinal malondialdehyde MDA of broilers fed with a feed challenged diet* containing different doses of Lumance.


Day 28


9 300 8 200 7 100 6


0 0


Lumance concentration (Kg/ton) 12


 *p value = 0.0248


34 ▶ GUT HEALTH | DECEMBER 2020


5 0


 12


Mean values ± SD are reported; n = 6 birds per treatment. *p values =0.0450


Interferon gamma (pg/ml)





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