ANTI-ACNE
Sayuri Hyodo, Shuichi Yamana – Vitamin C60 BioResearch Corporation, Japan
Fullerene: topical application for acne treatment
Acne vulgaris is one of the most common diseases of the skin and has increased in frequency over the last 50 years.2
Skin
diseases, such as acne, may not be life threatening but have been associated with depression, anxiety, and serious psychological damage in sufferers. Acne is characterised by the formation of non- inflammatory comedos and inflammatory papules, pustules, nodules, and cysts. Generally, the major pathogenic factors involved in acne are sebum overproduction, follicular hyperkeratinisation, and bacterial hypercolonisation, as well as immune reactions and inflammation. Androgens, microbes, and other pathogenic influences may also lead to acne, thus the disease has a complex pathogenesis.3 Sebum produced by sebaceous glands,
altered follicular contents, and reactive oxygen species (ROS) may release from
ABSTRACT
Acne vulgaris is a common dermatological disease with a multifactorial etiology. There has been an increasing focus on the role of oxidative stress in the pathophysiology of acne in recent years. Research has indicated that oxygen radical scavengers have potential as therapeutic agents for acne vulgaris. Fullerene (C60
) is a
collective term for spherical carbon allotropes that are potent antioxidants and reportedly react with various oxygen chemical species such as free radicals. It has been found that water-soluble fullerene inhibited the peroxidation of squalene induced by ultraviolet B. Moreover, Inui et al. reported that fullerene had a suppressive effect on
Normal Pore Sebum secretion↑ Sebum
Sebum oxidation, squalene etc.
accumulation Inhibition
Inflammatory exanthem COMEDO
ERYTHEMATOUS PAPULA
PUSTULE NODULE SCAR Inhibition Induction of inflammation and ROS Keratotic aberration
Propionibacterium acnes secretes lipase. ↓
Lipase generates free fatty acid (FFA) from sebum.
FFA induces more inflammation. ↓
Reactive oxygen species (ROS) accumulates by activated neutrophils.
Inflammation is worsened by ROS. sebum secretion.1 Inui et al. also
performed a clinical test using fullerene gel for the treatment of acne vulgaris; the mean number of inflammatory lesions decreased significantly after treatment for 8 weeks. Fullerene gel improved the acne vulgaris without causing any dryness of the skin or any changes in its barrier functions. The safety of fullerene material has been demonstrated by toxicity tests required for the approval of fullerene as an additive in quasi-drugs. These studies suggest that fullerene is a safe and novel skin care treatment for acne vulgaris. In this review, we report on aspects of the topical application of fullerene for the treatment of acne.
Pore plugged and swollen because of sebum
accumulation
Inlammatory state caused by increase in P. acnes
Pus-filled pocket with further inflammation
Figure 1: Pathogenesis of acne and inhibition effects by fullerene. 30 PERSONAL CARE March 2012
Sac-like enlarged pore
Indentation caused by the acne blemish
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