52 SKIN CARE ▲µS
120 100 80 60 40 20 0
-20 -40 -60
* * (1.2) (1.2) * (1.2) * (1.2)
2.5 2
Repeated applications
1.5 1
*(2) Baseline 2 hours * (2) 4 hours 6 hours 8 hours * (2) * (2) * (2) Repeated applications
Figure 5: Evolution of skin capacitance after repeated application of Soft Touch Hand Sanitizer (n=30). * significant versus control (1) and versus untreated (2) p<0.1
advantages of adding glycine betaine to hand sanitizer formulations; it both prevents skin dryness caused by repeated sanitizing,9 immediately moisturizes the horny layer.
and
Glycine betaine in hand cream provides long lasting moisturization The skin barrier function is improved by adding 3% glycine betaine to a skin care emulsion The clinical study was performed on 41 healthy volunteers with dry skin. Two products were tested: An oil in water (O/W) emulsion containing 3% of glycine betaine and an O/W emulsion without it, as a control. The O/W cream-gel was applied to the legs (2mg/cm²) twice a day for 29 days, with a six-day regression period without application from days 30 to 35. The skin barrier function was evaluated by measuring transepidermal water loss (TEWL) with a Tewameter (Courage & Khazaka, Germany). Measurements were taken before the first application and at Days 29, 31 and 35. The results demonstrate that twice daily application of an O/W emulsion containing
Baseline
0.5 0.0
-0.5 -1.0 -1.5 -2.0 -2.5
Day 0 TREATMENT PERIOD
Figure 6: Evolution of visual dryness score after repeated application of Soft Touch Sanitizer(n=30). * significant versus control (1) and versus untreated (2) p<0.1
3% glycine betaine significantly decreases transepidermal water loss after only 3 days of use. The effect is increased after 29 days of application and remains significant for two days after the last application (Fig 7).This study clearly demonstrates that glycine betaine significantly strengthens the skin barrier. Applied in an O/W emulsion glycine betaine may help to protect the skin from barrier disruption and skin irritation caused by repeated use of detergents or hand sanitizers.
Conclusion Adding GENENCARE OSMS BA with 99% pure glycine betaine to hand care routine products is an excellent way to mitigate the damaging impacts of surfactants, maintain soft smooth skin even with frequent washing, and improve skin moisturization. GENENCARE OSMS BA also improves the skin barrier function when added to hand creams. GENENCARE OSMS BA mitigates the
skin damage caused by frequent hand washing. It has moisturization, protection and sensorial benefits and is a must for today’s new hand care routines.
REGRESSION PERIOD PC
References 1 Boyce J, Chartier Y, Chraïti MN, et al. WHO guidelines on hand hygiene in health care. First global patient safety challenge. Clean care is safer care. World Health Organization 2009. Switzerland. WHO Library Cataloguing- in-Publication Data; 2009, 54–113
2 Beiu C, Mihai M, Popa L, et al. Frequent Hand Washing for COVID-19 Prevention Can Cause Hand Dermatitis: Management Tips Cureus. 2020; 12(4): e7506.
3 Warskulat U et al. The Osmolyte Strategy of Normal Human Keratinocytes in Maintaining Cell Homeostasis, Journal of Investigative Dermatology, 2004, Volume 123, Issue 3, 516 – 521.
4 Pericu P, Gherardi C, Lambers H. Discovering the invigorating osmolyte, Personal Care Europe, Sept 2019: 107-110
5 Putaala H, Tiihonen K, Rautonen N. Betaine increases tight junction integrity in epidermal keratinocytes, S27-S27, Journal of Investigative Dermatology 2010; Conference: 40th Annual Meeting of the European Society for Dermatological Research, Volume: 130
6 El-Chami C, Haslam IA, Steward MC, O’Neill CA. Role of Organic Osmolytes in Water Homoeostasis in Skin, Exp Dermatol. 2014; 23(8):534-7
7 Gotte E, et al. Synthetische Tenside in medizinisch-kosmetischen Biiden, Aest. Medizin. 1966; 15: 313- 32O
* * * Day 3 Time (hours)
Figure 7: Evolution of transepidermal water loss (g/m2/h) after repeated application during 29 days of a O/W emulsion containing 3% of GENENCARE®
OSMS BA (n=41). * significant versus control p<0.05 PERSONAL CARE NORTH AMERICA Day 29 Day 31 Day 35
8 Nicander I, Rantanen I, Rozell BL, Söderling E, Ollmar S. The ability of betaine to reduce the irritating effects of detergents assessed visually, histologically and by bioengineering methods, Skin Res Technol. 2003;9(1):50-58
9 Pawar M. Overzealous hand hygiene during the COVID 19 pandemic causing an increased incidence of hand eczema among general population, J Am Acad Dermatol; 2020: 83(1):37 – 41
10 “Soft Touch Hand Sanitizer.”
https://www.ulprospector.com/en/eu/Person alCare/Detail/6817/646867/2016-Soft-Touch- Hand-Sanitizer
October 2020
0.5 0
Baseline (* 1.2) 2 hours *(2) *(2) 4 hours *(2) * (2) 6 hours * (1,2) 8 hours 24 hours 3
*
(2)
* (1,2)
∆TEWL
Moisturization Mean increase in skin conductance response versus untreated (%)
Moisturization Visual dryness score evolution
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