44 SKIN MICROBIOME


Respecting microbiome for wellbeing and body odor


n Ò. Expósito, A. Guirado, D. Robustillo, R. Vallecillo, A. Gallego, M. Mas, P. Riera, S. Ruiz, D. Luna, S. Laplana, T. Ruiz - Vytrus Biotech, Spain


Consumers are just beginning to accept and understand the importance of their skin microbiota and are increasingly keen to seek out products that either maintain or enhance the living world within their skin. Vytrus Biotech have designed two active ingredients that work with the skin microbiota in very different ways; one ingredient modulates the skin neurochemical networks and enhances the feeling of comfort and self-confidence through the Microbiota-Skin-Brain Axis, while the second ingredient is a deodorant treatment that allows the axilla to perspire, avoiding bad odor generation, while respecting the skin microbiota.


Cannabis sativa stem cells to nourish microbiota The skin microbiota and the brain are connected through an existing natural pathway where the microbiota is the first step. The new active Kannabia SensePLF (INCI name: Cannabis Sativa Callus Lysate), is the first generation of Cannabis sativa plant stem cells and introduces the concept of in situ postbiotic. Through its mechanism of action, the active modulates the skin commensal microbiota to produce a positive in situ postbiotic cocktail that ignites the synthesis of happiness related neurochemicals from the skin that connects with the brain, turning into a wellbeing response and a healthier and stronger skin.


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Control (untreated) Figure 1:Oxytocin levels in NHE. PERSONAL CARE NORTH AMERICA 0.003% KANNABIA SENSEPLF


Several in vitro and in vivo trials have been carried out to demonstrate the skin well- aging effect, positive brain activation and modulation of mood state thanks to the active ingredient.


The microbiota-skin-brain axis The skin is a neuroendocrine organ able to synthesise a plethora of neuropeptides and neurotransmitters such as oxytocin, serotonin, -endorphin, etc. The microbiota is the most superficial


layer of the skin and has much more metabolisation potential than human cells. In fact, this microbiota gives our skin cells an increased metabolism capacity to perceive and manage all information that comes from the environment and within the body. Microbiota can interfere in the skin


neurochemical networks and enhance the production of wellbeing-linked molecules like oxytocin (the happiness hormone) by the synthesis of an in situ postbiotic cocktail. The skin microbiota can metabolise a


plant cell culture-derived ingredient and produce an in situ postbiotic that significantly increases the synthesis of oxytocin by the skin keratinocytes and sensory neurons. This postbiotic is produced by the commensal microbiota locally (in situ) and directly on the skin and stimulates the skin cells to ignite the synthesis of positive neurochemicals. Those ‘excited’ keratinocytes could stimulate the


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0.003% bSN


Control (untreated)


0.003% bSN


Figure 2:Oxytocin levels in sensory neurons. October 2020 1% kSN


skin nerve endings and connect the skin directly with the brain with the aim of stimulating and reinforcing a positive loop of communication between the skin and the brain that ends up in a skin with a better health and appearance. Considering the great impact of


emotions and wellbeing on the skin homeostasis and appearance, it is essential to consider the microbiota-skin-brain axis in this new cosmetic strategy.


The new active Through the new active Kannabia SensePLF


,


it is possible to stimulate the skin microbiota to produce an in situ post-biotic cocktail that stimulates the synthesis of cutaneous oxytocin. The oxytocin generated in the keratinocytes connects with the sensory neurons and communicates with the brain turning into a wellbeing response that ends up in a healthier, stronger, and more beautiful appearance. This active (INCI name: Cannabis Sativa


Callus Lysate) is the first active made from Cannabis sativa plant stem cells and has been obtained through the proprietary Technology Platform Phyto-Lipidic Fractions. It has been enriched with a great and diverse cocktail of plant terpenes and polyphenols while avoiding the production of the controversial cannabinoids THC and CBD. Once metabolized by the skin


Oxytocin levels (pg/ml)


Oxytocin levels (relative to BCA)


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