SKIN MICROBIOME 13


An original solution beyond skin microbiome


n Véronique Maurin, Yicheng Xu – Biocosmethic, France


Human skin is a large, heterogeneous organ that protects the body from pathogens while sustaining microorganisms that influence human health and disease. It provides habitat for a variety of microorganisms: the microflora of the skin and there is a complex network of interactions between microbes and epidermal cells. This protective barrier against mechanical, thermal, physical injury or noxious agents, contains a dynamic immune system, which allows it to actively fight against infections. This system is also vital in wound-healing and modulates the commensal microbiota that colonizes the skin. The balance between commensal


microbiota and epidermis is delicate and needs to be tightly regulated. However, environmental air pollutants, hard water or chemicals are factors affecting skin integrity and contribute to the variation of skin microbiota, resulting in a constant increase in sensitive skin prevalence, a complex issue mainly associated with dry or reactive skin due to climatic environmental factors and cosmetics. Those factors including soaps or cosmetics have been reported to potentially contribute to the variation of skin microbiota.1


The Coronavirus pandemic has


unquestionably had an extreme impact on on our daily life. Hygiene habits, such as washing hands with soap and using hand sanitizers have drastically increased. Unfortunately, the frequent use of these


Abstract


Human skin is a large, heterogeneous organ that protects the body from pathogens while sustaining microorganisms that influence human health and disease. It provides habitat for a variety of microorganisms: the microflora of the skin and there is a complex network of interactions between microbes and epidermal cells. Although skin is a protective barrier against mechanical, thermal, physical injury or noxious agents, it contains a dynamic immune system, allowing it to actively fight against infections. The balance between commensal microbiota and epidermis is delicate and need to be tightly regulated. In dermal remodeling, communication between keratinocytes and fibroblasts is also essential to maintain homeostasis or to responds to stress induced by micro-organisms, pollution, UVs… Kalmethic®


thanks to its ability to firstly positively


modulate skin-microbiota interaction and secondly to regulate skin aging pathways and dermal remodeling highlighted by exosome-based dermal communication, represents an interesting, original and innovative solution to restore skin homeostasis and address sensitive skin concerns. Dedicated to sensitive skins, Kalmethic offers a natural and powerful solution, Cosmos approved and Natrue compliant, with a very safe profile to restore and protect skin barrier function exposed to external aggressions while reducing sensitive skin’s discomfort, repressing aging and senescence processes for a more beautiful skin.


surfactant-based products in combination with alcohol results in dry and rough skin. As the barrier function of the skin is impaired, the skin becomes more prone to irritations, infections and even atopic skin conditions. These modified hygienic practices and lifestyle changes have the potential to selectively alter the skin microbiome and may underlie the increased incidence of skin reactivity and cutaneous discomfort (Fig 1). Therefore, the maintaining or rebalancing this delicate harmony is essential for preserving skin homeostasis.


Environmental air pollutants impact on skin microbiota The balance between skin health and disease is delicate. Certain dermatological disorders manifest at stereotypical skin sites [e.g., psoriasis on the outer elbow and atopic dermatitis (eczema) on the inner bend of the elbow]. Moreover, antibiotic exposure, modified hygienic practices, and lifestyle changes have the potential to selectively alter the skin microbiome and may underlie the increased incidence of human disorders such as atopic dermatitis. The normal microflora of the skin


includes staphylococcal species that will induce inflammation when present below the dermis but are tolerated on the epidermal surface without initiating inflammation. Microbes are predicted to play a role in


Figure 1: Skin microbiota imbalance and its consequences October 2020


the pathophysiology of many common dermatoses with predilection for specific skin sites (e.g., atopic dermatitis, psoriasis, acne, seborrheic dermatitis). Targeted therapies to maintain healthy skin might require not only inhibiting the growth of pathogenic bacteria, but also promoting the growth of symbiotic bacteria such as S.epidermidis.2


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