46 SKIN MICROBIOME
versus placebo at 28 days and up to 50% in glow intensity versus initial time.
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In vivo 2: Evaluation of the emotional modulation For this in vivo assay, there was a panel compound of 30 volunteers (46 -69 years old) who were applied a 2% active dosage in a double-blind study vs placebo on 2 daily applications. l Analysis of the brain activation by functional Magnetic Resonance Imaging (fMRI) In order to test the efficacy of the active
the volunteers’ brain activity was analyzed by functional Magnetic Resonance Imaging (fMRI), a sophisticated technique that measures the changes in brain activity associated with changes in blood flow, which is associated with the neuronal activation of a specific area. This allows to detect which brain areas are
activated after applying the active and the relationships between different brain areas through the calculation of correlation coefficients. For this in vivo brain analysis, 132 brain
regions were analyzed on the 20-volunteer subgroup to evaluate the brain connections after the application of a lotion containing 2% dosage of the active in order to understand how it activates in vivo the different brain pleasures areas of the participants. Compared to placebo, the results showed
that the active demonstrated a higher positive brain activation at 15 minutes than placebo after application, while producing an even higher positive activation of the brain pleasure zones at 28 days (Fig 4). The active demonstrated a higher
10000000 Before After +
2 1 0
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n Placebo cream n Cream containing 2% Kannabia Sense PLF
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35 30 25 20 15 10 5 0
+29% +18% +8.5% +8.5% Optimistic Joyful Cheerful Happy
Optimistic
Happy
Joyful
Cheerful
Figure 5: Clinical evaluation of the positive emotions.
activation of regions and significant brain connections than placebo, being those associated with the touch sense and affective processes, especially being the anterior cingulate cortex (ACC) and pallidum zones (part of the “lentiform nucleus” region which in turn is part of the “striate body”), the most relevant parts of the study and, also, a considerable activation of the orbitofrontal cortex (OFC). It has been demonstrated that the ingredient activates and connects the same brain regions both immediately and in the long-term the subcallosal cortex and the temporal gyrus with the amygdala. Furthermore, the palladium and the
amygdala on one hand, and the anterior cingulate cortex and the subcallosal cortex on the other hand, are regions especially
involved in the response to oxytocin and all located in proximity. The active showed an activation profile like
oxytocin, demonstrating its ability to activate the neuroendocrine skin-brain axis, similar to touch and massage and its emotional effectiveness. This activated brain pleasure regions that are related to a greater social predisposition and attractiveness of the person. l Modulation of mood state The emotions generated in the 30
volunteers after the application of a cream containing 2% of the active were also analyzed. The positive emotions of the volunteers increased up to 29% and the volunteers declared to feel more relaxed, confident and happier (Fig 5).
1000000
100000
10000
C.acnes
S. aureus
P.aeruginosa Figure 6: Analysis of the broad spectrum bacteriostatic and fungistatic effect. PERSONAL CARE NORTH AMERICA October 2020
C.striatum
E. floccosum
M.furfur
C.F.U.
Inoculum Day 0 Control (24h) 3% NONI PRCF
Inoculum Day 0 Control (24h) 3% NONI PRCF
Inoculum Day 0 Control (24h) 3% NONI PRCF
Inoculum Day 0 Control (24h) 3% NONI PRCF
% Improvement versus placebo Positive emotions
Inoculum Day 0 Control (24h) 3% NONI PRCF
Inoculum Day 0 Control (24h) 3% NONI PRCF
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