32 BODY CARE LACTATE ADSORPTION COMPARISON TEST
2.5 2
1.5 1
0.5 0
complex HAP Zeolite Mg (OH)2 + Mg5 (CO3)4(OH)2
Figure 2: HAP complex showed higher lactate adsorption capacity than zeolite and magnesium salts in artificial sweat
This positive result is attributed to the
reduction in sweating having exceeded 20% in at least 50% of the target population (p < 0.05). After 48 hours, the mean amount of sweat collected from the test formulation-treated armpits resulted in a lower mean value of 30.5%, compared with the placebo treatment. Statistical analysis confirmed the sweat control efficacy of the test formulation at 48 hours, again according to FDA guidelines.
Conclusion In summary, the HAP complex emerges as a groundbreaking solution for sweat and odour control, offering good performance and versatility across various cosmetic applications.
TABLE 7: SWEAT PRODUCTION OF HAP COMPLEX VERSUS PLACEBO
Time
t=24 hr t=48 hr
HAP complex formulation 0.302 0.501
Placbo 0.528 0.790
Control
0.9 0.8 0.7 0.6 0.5 0.4 0.3 0.2 0.1 0
SWEAT AMOUNT (grams) HAP complex formulation ■ Placebo ■
t 24h
t 48h Figure 3: Gravimetric test: sweat reduction at 24 and 48 hours
Unlike traditional actives which present issues such as skin irritation, microbiota disruption and pH dependency, the HAP complex addresses these limitations through its biomimetic hydroxyapatite structure. This innovative material ensures effective adsorption of sweat and odour-producing compounds, such as ammonia and lactate, while maintaining skin homeostasis and microbiota balance. The in vitro and in vivo studies underscore
the HAP complex’s ability to outperform conventional materials like zeolites and magnesium salts, with demonstrated reductions in sweat and enhanced odour neutralization. Furthermore, its compatibility with a wide range of formulations - from sprays to creams
TABLE 8: MEAN % OF SWEAT PRODUCTION OF THE HAP COMPLEX VERSUS PLACEBO
Time
t=24 hr t=48 hr
Placbo
-35.5% -30.5%
and anhydrous systems - ensures a seamless integration into diverse cosmetic products. The unique sensory profile, characterized by its invisible and non-irritating nature, adds to its consumer appeal. This multifunctional ingredient not only
provides a sustainable alternative to traditional actives but also sets a new standard in deodorizing efficacy, formulation flexibility, and dermo-compatibility. Its adoption could redefine the future of personal care products, aligning high performance with enhanced safety and user comfort.
PC
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2. Urban J, Fergus D, Horvath J et al. (2016). The effect of habitual and experimental antiperspirant and deodorant product use on the armpit microbiome. PeerJ. 2016; 4 e1605.
3. Quatrale R, Waldman A, Rogers J, Felger C. The mechanism of antiperspirant action by aluminum salts. (I) The effect of cellophane tape stripping on aluminum salt-inhibited eccrine sweat glands. J Soc Cos Chem. 1981; 32 67-73
4. Graziani G, Boi M, Bianchi M. A review on ionic substitutions in hydroxyapatite thin films: Towards complete biomimetism. Coatings. 2018; 8 269
5. Roveri N, Foresti E, Lelli M, Lesci I. Recent advancements in preventing teeth health hazard: The daily use of hydroxyapatite instead of fluoride. Recent Patents on Biomedical Engineering. 2009; 2 197-215
6. Nishida H, Kimata M, Ogata T, Kawai T. Malodors adsorption behavior of metal cation incorporated hydroxyapatite. J Envt Chem Engineering. 2017; 5 2815-2819
7. Majors P, Wild J. The evaluation of antiperspirant efficacy–Influence of certain variables. J Soc Cos Chem. 1974; 25 139-152
PERSONAL CARE February 2025
www.personalcaremagazine.com
% (w/w) Adsorbed Lactate/24 hours 37°C
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