SKIN CARE Bakuchiol Ester BCR Expert Grading 20 15.52% 15 10 7.14% 5 0 Fine Line/Wrinkles Firmness (visual) Assessment


Figure 9: Results of a clinical study on patients using an anti-ageing serum with 1% bakuchiyl salicylate. Subjects were assessed for visual improvements in fine lines/wrinkles, firmness, elasticity, and sagging. Significant improvements were found for all endpoints after both eight weeks and 12 weeks of treatment


generation bakuchiol-derived actives that feature enhancements in skin penetration, mildness, and activity. Bakuchiol Ester BCR (Bakuchiyl Salicylate) is an ester of bakuchiol and salicylic acid that is dispersed in Vitamin F Glyceryl Esters. As compared to bakuchiol, bakuchiyl


salicylate has four times higher permeation in skin modeling tests (STRAT-M), multifold lower cytotoxicity, and enhanced activity (such as greater hyaluronic acid boosting effect). A pilot study was done on bakuchiyl


salicylate where 12 patients applied a face serum containing 1% bakuchiyl salicylate for 12 weeks. The clinical study showed an improvement in the appearance of saggy skin, increased skin plumpness, elasticity, and firmness. All of these endpoints fit into our theoretical guidelines for mitigating Ozempic face.


Advanced glycation ends We have reviewed the detrimental impacts that Ozempic can have on the face, but it is also important to mention the potential benefits. GLP-1 Agonists help treat diabetes by increasing the amount of circulating insulin which helps cells internalize glucose. This effectively reduces blood sugar levels and, as a consequence, may reduce the formation of advanced glycation end products (AGEs). AGEs are detrimental compounds that form


when reducing sugars (such as glucose) come into contact with proteins (such as collagen) and react with each other through several intermediate steps. Individuals with unhealthy dietary habits (high in simple sugars) or with diabetes are especially prone to accumulating AGEs, however this process happens naturally in chronological ageing as well.13 AGEs can contribute to skin ageing through


multiple ways. In one way, AGEs result in a cross link chain reaction with extracellular matrix components like collagen. Excessive cross-linking can cause a stiffening effect and reduces the elasticity of skin. It can also interfere with the signalling activities of


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