26 SKIN CARE
collagen, such as the binding of fibroblasts to extracellular collagen which is one of the ways fibroblasts are stimulated to produce more collagen. Furthermore, AGE-collagen complexes
are resistant to degradation which means reversing this process is difficult. AGEs combined with photoageing can cause skin to become leathery and dry. Additionally, AGEs have their own receptors called receptors for ages (RAGEs). RAGE activity can cause a sustained inflammatory response that can lead to degradation of extracellular matrix components, production of ROS, and reinforce the expression of more RAGEs in a vicious cycle.13
The link between diabetes, ageing, and
AGE accumulation has been noted in patient populations as well. One particular study that was performed on over 900 patients across three community health centres found a significant correlation between AGEs, high body mass index (BMI), diabetes, and even prediabetes.14
Conclusion Challenge is the fuel of innovation, it allows for familiar tools to be used in new ways, and for the creation of new tools to usher new possibilities. In the ever shifting landscape of cosmetics, Ozempic is that new challenge. Peptides, retinoids, and bakuchiol are some of the familiar tools that rise to the occasion. Miniproteins and next-generation retinoid/ bakuchiol technologies are the new tools that venture into uncharted waters. As a groundbreaking weight loss and
diabetes treatment, Ozempic has already had a lasting impact on society. The effects of Ozempic are multifactorial and complex, carrying both benefits and detriments to skin biology. One the one hand, it may potentially
help reduce AGE-related skin deterioration, however it also exacerbates visual signs of ageing such as crepey skin and wrinkles. As we mould and sculpt the details of its inner workings, we expand our knowledge and power with every touch. This is the art of science and our guiding light to the future.
Collagen crosslinks Elasticity Stiffness Degradation
AGEs ROS
Fibroblasts Apoptosis Senecence Cell growth ECM synthesis
MAPK Jak/Stat
RAGE RAGE
NOX ROS
NFkB activation
Vimentin crosslinks Migration Division
SOD, catalase
TNF-a, IL-1, IL-6 RAGE p65
DNA damage
Endothelial cells VCAM, ICAM Permeablity TNF-a, IL-6 MCP-1
Figure 10: Illustration of the role advanced glycation ends (AGEs) play in inflammation and skin ageing. AGEs can influence inflammation through reactive oxygen species (ROS), receptors for advanced glycation ends (RAGEs), and direct influences on extracellular matrix components13
facial_volume_loss_aging.html PC
References 1. Mansour MR, Hannawa OM, Yaldo MM, Nageeb EM, Kongkrit Chaiyasate. The Rise of “Ozempic Face”: Analyzing Trends and Treatment Challenges Associated with Rapid Facial Weight Loss Induced by GLP-1 Agonists. Journal of Plastic Reconstructive & Aesthetic Surgery. 2024; Sep 1;96:225–7
2. Masri S, Zawani M, Zulkiflee I, Salleh A, Fadilah NIM, Maarof M et al. Cellular Interaction of Human Skin Cells towards Natural Bioink via 3D-Bioprinting Technologies for Chronic Wound: A Comprehensive Review. International Journal of Molecular Sciences. 2022; Jan 1;23(1):476
3. Facial Volume Loss. Aging and Facial Sagging Due to the Age Related Volume Loss. MAIPS - Medical Aesthetics Information Platform and Solutions.
https://www.maips.com/
PERSONAL CARE February 2025
4. Rocha RI, Junior WC, Modolin MLA, Takahashi GG, Caldini ETEG, Gemperli R. Skin Changes Due to Massive Weight Loss: Histological Changes and the Causes of the Limited Results of Contouring Surgeries. Obesity Surgery. 2021; Apr 1;31(4):1505–13
5. Sami K, Elshahat A, Moussa M, Abbas A, Mahmoud A. Image analyzer study of the skin in patients with morbid obesity and massive weight loss. Eplasty. 2015; Jan 1;15:e4–4
6. Thornton MJ. Estrogens and aging skin. Dermato-Endocrinology. 2013 Apr 1;5(2):264– 70
7. Hetemäki N, Mikkola TS, Tikkanen MJ, Wang F, Hämäläinen E, Turpeinen U et al. Adipose tissue estrogen production and metabolism in premenopausal women. The Journal of Steroid Biochemistry and Molecular Biology. 2021; May; 209:105849
8. Zhang Y, Jain R, Zhu M. Recent Progress and Advances in HGF/MET-Targeted Therapeutic Agents for Cancer Treatment. Biomedicines. 2015; Mar 19;3(1):149–81
9. Zomer HD, Cooke PS. Targeting estrogen signaling and biosynthesis for aged skin repair. Frontiers in Physiology. 2023; Oct 31;14
10. Chajra H, Saguet T, Granger C, Breton L, Pinto PC, Machicoane M, et al. A New TGF-β Mimetic, XEPTM-716 MiniproteinTM, Exhibiting Regenerative Properties Objectivized by Instrumental Evaluation. Dermatology and Therapy. 2024; Sep 19
11. Ud-Din S, McGeorge D, Bayat A. Topical management of striae distensae (stretch marks): prevention and therapy of striae rubrae and albae. Journal of the European Academy of Dermatology and Venereology. 2015 Oct 20;30(2):211–22
12. Bacqueville D, Maret A, Noizet M, Duprat L, Coutanceau C, Georgescu V, et al. Efficacy of a Dermocosmetic Serum Combining Bakuchiol and Vanilla Tahitensis Extract to Prevent Skin Photoaging in vitro and to Improve Clinical Outcomes for Naturally Aged Skin. Clinical, Cosmetic and Investigational Dermatology. 2020; May; Volume 13:359–70
13. Gkogkolou P, Böhm M. Advanced glycation end products. Dermato-Endocrinology. 2012 Jul;4(3):259–70
14. Jiang T, Zhang Y, Dai F, Liu C, Hu H, Zhang Q. Advanced glycation end products and diabetes and other metabolic indicators. Diabetology & Metabolic Syndrome. 2022; Jul 25;14(1)
www.personalcaremagazine.com
Immune cells Proliferation Chemotaxis TNF-a, IL-1, IL-6
Matrix degradation MMPs TIMPs
Actinic elastosis
UV irradiation Keratinocytes
TNFa, IL-1, IL-6 ROS Integrin a2
β1
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