Laboratory Products 49 How to Prevent your Cake from Collapsing in Freeze Dried Products
Freeze drying is a crucial process for a variety of industries, especially pharmaceutical and biotech as it extends the shelf-life of products and makes the material safer and more convenient for transportation.
Many drugs are unstable in solution and degrade rapidly over time, therefore they must be freeze dried to produce a suitable stable product which can be shipped and has an acceptable shelf-life for storage. The freeze dried product can be reconstituted to produce a solution containing the drug ready for administration. Different drugs can be stabilised by freeze drying, these include small molecules but also biological treatments such as vaccines, proteins, enzymes, and other larger molecules.
Freeze drying API/ drug products comes with its own unique challenges and stability issues which need to be overcome. Many biological drug products require additional excipients to stabilise them during the freeze drying process and during storage.
These excipients typically stabilise the drug molecules by entrapping protein molecules in an amorphous matrix which reduces the mobility of the molecule slowing its degradation, and also by supporting the structure of the molecule when freeze dried by replacing the hydrogen bonds interactions of water, which maintain the structure of the molecule in solution, allowing its structure to be maintained once the water has been removed. The resulting product is commonly a freeze dried ‘cake’.
The freeze drying process to produce a ‘cake’ can be broken down into three main stages; freezing, primary drying and secondary drying. In order to achieve a successfully freeze dried product, the optimised formula which gives you the best results needs to be developed. Biopharma Group can provide you support throughout the formulation development process including your pre-formulation study. With in- house equipment and expertise, Biopharma can perform DSC analysis, freeze drying microscopy (FDM), critical event frozen state analysis, MicroPress cake robustness analysis and much more.
More information online:
ilmt.co/PL/R4xO 49290pr@reply-direct.com
New Line of Products for Critical Processes in the Medical and Pharmaceutical Industries Introduced
Mokon is an international leader in high-quality circulating liquid temperature control systems since 1955. The company recently introduced a line of high- performing equipment designed for critical environments in the medical and pharmaceutical industries. Applications include biotechnology and pharmaceutical, extrusion, laboratory, medicine and vitamin processing, mixers and blenders, packaging, personal care/cosmetics, plastic injection and blow moulding, reactors, sterilisers and fermenters, surgical equipment and devices, and vessels/ jacketed tanks.
Mokon’s new line of Pura-Therm sanitary designs including circulating water, portable chillers, and combination chilling and heating systems are designed and built for cleanroom and sanitary environments. The equipment will meet ISO Standards for Cleanroom and associated controlled environments with stainless steel materials. Equipment will feature NEMA 4X rated panels and wash down designs, and stainless steel cabinets. Temperatures range from -20°F (-29°C) up to 380°F (193°C).
“The addition of this line of cleanroom/sanitary products provides our medical and pharmaceutical customers with a greater selection for their process heating and cooling requirements,” said Rob Kennery, Vice President of Sales and Marketing. “Mokon is always striving to meet the needs of our customers with a wide range of customisation options and accessories.”
Mokon is interested in collaborating with companies who manufacture OEM type equipment i.e. vessels, mixers, reactors, etc. and need process control systems alongside their equipment. Please contact Rob Kennery of Mokon at
rob.kennery@
mokon.com.
Mokon’s circulating liquid heating and chilling equipment is proudly designed and manufactured in the USA. Mokon is an ISO 9001 and ISO 14001 certified company.
More information online:
ilmt.co/PL/ZvrK 49162pr@reply-direct.com
Awareness is the Key that Unlocks Increased Safety in the Lab
You may not be able to detect chemical emissions in your lab, but Erlab’s Halo Sense can.
The Halo Sense is a small, portable unit that monitors the air quality in your lab to detect a broad-range of VOCs or acids at the source (a formaldehyde version is also available). If chemical emissions are detected, the light will pulse with an audible alarm so that you can take the next steps to ensure your safety.
44883pr@reply-direct.com
Multi-Mode Microplate Reader now Available with TRF Laser
BioTek’s Synergy™ Neo2 Multi-Mode Microplate Reader offers even more powerful performance and assay flexibility for screening and core laboratories with an optional TRF laser. Along with dual photomultiplier tube (PMT) detection, the 337 nm laser provides the exceptional processing speed and maximum sensitivity necessary for high-quality time-resolved fluorescence (TRF) and time-resolved fluorescence resonance energy transfer (TR-FRET) results.
Synergy Neo2 provides a wide range of capabilities to facilitate an endless number of high- throughput biochemical and cell-based assay workflows. Patented Hybrid Technology™, with variable bandwidth quad monochromators and sensitive high-transmission filter optics, enables wide flexibility in assay choice. Advanced environmental controls, including incubation to 65ºC, CO2
/O2 regulation, and variable shaking, along with direct bottom detection, support live cell
assays. Gen5™ Software controls Synergy Neo2 and enables powerful data analysis. Synergy Neo2 may be linked with BioTek’s BioStack™ Neo or third-party robotic systems for walk-away automation and further enhanced throughput, and may also be easily integrated with any laboratory information management system (LIMS).
More information online:
ilmt.co/PL/R4n4 49047pr@reply-direct.com
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