The Bioanalysis Glossary EQUATIONS • 1 Bioavailability


AUCextravascul AUCi


- -


ntravascul


ar ar


where AUC typically refers to plasma AUC


• 2 Fraction unbound (Fu): -


Fu = 1 PC PF PC


- ()


where PC = Test compound concentration in protein-containing compartment PF = Test compound concentration in protein-free compartment


• 3 • 4 %Bias


IS norm alzedM atri - i % • 5 %CV %


CV Mean measured conc Standard Devi


=


• 6 %Recovery =


ati ()on SD # 100 .


%Recovery mean peak ratio area(post extraction spiked samples) mean peak area ratio(extractedsamples)


- xFactor Mean AreaRati nAbsenceofMatri


= Peak AreaRati nPresenceofM atri oi


oi


Bi ..as Nomi


= Mean measured conc Nomi nalconc.


- nalConc 100#


x x


# 100


S92


Bioanalysis (2016) 8(21) Suppl. 1


future science group


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