The Bioanalysis Glossary • 63 cell-based neutralizing antibody assay


Method for the detection or quantitation of neutralizing antidrug antibodies (ADA) that block the functional properties of the drug. These assays utilize a cell line that is responsive to the drug either by directly responding to it or by responding to a ligand that shows altered activity in the presence of drug.


• 64 centrifugation


A process that involves the use of centrifugal force for the sedimentation of heterogeneous mixtures with a centrifuge. In bioanalysis, it is often used to separate blood from plasma, to separate protein precipitates from the liquid fraction, pellet suspended cells or to separate two immiscible solvents during liquid–liquid extraction.


• 65 certificate of analysis (CoA)


A document that shows the characterization of a reference standard and suitability to be used to support good laboratory practice (GLP), good clinical practice (GCP) or good manufacturing practice (GMP) studies.


• 66 chaotropes


Chaotropes are poorly hydrated solutes, disrupting hydrogen bonding and causing disorder to the structure of water.


• 67 chiral chromatography


Chromatographic technique that is capable of separating enantiomers via diastereomeric complex formation with differential partitioning into the mobile phase.


• 68 chiral compound A compound that contains one or more asymmetric center(s).


• 69 chiral inversion


Enzyme- or chemically-mediated conversion of one enantiomer to its antipode (opposite enantiomer) with no other change in the molecule.


S20 Bioanalysis (2016) 8(21) Suppl. 1 future science group


Page 1  |  Page 2  |  Page 3  |  Page 4  |  Page 5  |  Page 6  |  Page 7  |  Page 8  |  Page 9  |  Page 10  |  Page 11  |  Page 12  |  Page 13  |  Page 14  |  Page 15  |  Page 16  |  Page 17  |  Page 18  |  Page 19  |  Page 20  |  Page 21  |  Page 22  |  Page 23  |  Page 24  |  Page 25  |  Page 26  |  Page 27  |  Page 28  |  Page 29  |  Page 30  |  Page 31  |  Page 32  |  Page 33  |  Page 34  |  Page 35  |  Page 36  |  Page 37  |  Page 38  |  Page 39  |  Page 40  |  Page 41  |  Page 42  |  Page 43  |  Page 44  |  Page 45  |  Page 46  |  Page 47  |  Page 48  |  Page 49  |  Page 50  |  Page 51  |  Page 52  |  Page 53  |  Page 54  |  Page 55  |  Page 56  |  Page 57  |  Page 58  |  Page 59  |  Page 60  |  Page 61  |  Page 62  |  Page 63  |  Page 64  |  Page 65  |  Page 66  |  Page 67  |  Page 68  |  Page 69  |  Page 70  |  Page 71  |  Page 72  |  Page 73  |  Page 74  |  Page 75  |  Page 76  |  Page 77  |  Page 78  |  Page 79  |  Page 80  |  Page 81  |  Page 82  |  Page 83  |  Page 84  |  Page 85  |  Page 86  |  Page 87  |  Page 88  |  Page 89  |  Page 90  |  Page 91  |  Page 92  |  Page 93  |  Page 94  |  Page 95  |  Page 96  |  Page 97  |  Page 98  |  Page 99  |  Page 100  |  Page 101  |  Page 102  |  Page 103  |  Page 104  |  Page 105  |  Page 106  |  Page 107  |  Page 108  |  Page 109  |  Page 110  |  Page 111  |  Page 112  |  Page 113  |  Page 114  |  Page 115  |  Page 116  |  Page 117