Terms & Definitions • 158 immunoaffinity chromatography


Type of liquid chromatography in which the stationary phase consists of an antibody or antibody-related agent. The method can be used in assays for a particular target or for purification and concentration of analytes prior to further examination by another technique.


• 159 immunoassay


Technique that uses the specific recognition and binding of antibodies to an analyte (protein or other molecule) in order to detect or quantify the analyte.


• 160 immunocapture Direct capture of a molecule by an antibody immobilized onto a surface.


• 161 immunogen


A molecule (e.g., protein, small molecule-carrier protein conjugate) that will elicit antibodies in animals and, sometimes, humans upon repeated treatments.


• 162 immunogenicity


The ability of a molecule, usually with reference to a therapeutic (e.g., protein, nucleic acid, carbohydrate, lipid or small molecule) to provoke an immune response in the body of a human or animal.


• 163 immunogenicity assay


Method to detect an immune response to an administered therapeutic (usually a protein) in biological fluids (usually serum or plasma).


• 164 imprecision


Equivalent meaning to precision, pertaining to the degree of proximity or agreement of measurements within a replicate set, without reference to any given nominal or true value. Usually assessed using at least six replicate measurements.


future science group www.future-science.com S41


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