The Bioanalysis Glossary • 263 parallel reaction monitoring (PRM)


In PRM, the third quadropole of mass spectrometer is substituted with a high resolution and accurate mass analyzer to permit the parallel detection of all target product ions in one, concerted high resolution mass analysis.


• 264 parallelism


A condition in which dilution of test samples does not result in biased measurements of the analyte concentration. Determined for immuno- assays by comparison of the responses from the calibration standard curve and serially diluted study samples in order to detect possible matrix effect or differing affinities for metabolites


• 265 paratope The part of an antibody that recognizes an antigen.


• 266 parent ion


In mass spectrometry, an electrically charged molecular moiety that may dissociate to form fragments, one or more of which may be electrically charged, and one or more neutral species. Also called "precursor ion".


• 267 partial least squares regression (PLS)


Well-established regression-based method thanks to its ability to deal with many correlated variables or in situations where fewer observations than measured variables are available. PLS builds a low-dimensional sub-space by maximizing the covariance between the data and the class assignment. Orthogonal partial least squares analysis (O-PLS) and O2-PLS are recent extensions of the PLS method applied to metabolomic data.


• 268 partial validation


Series of analytical experiments where only relevant parts of the validation are repeated after method modifications or transfer of an existing fully validated bioanalytical method.


S62


Bioanalysis (2016) 8(21) Suppl. 1


future science group


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