The Bioanalysis Glossary • 100 discriminative metabolomics


The process of comparing the metabolites present in multiple samples collected under different conditions (e.g., disease states, drug treatment, among others) conducted to identify which metabolites are associated with the different conditions under which the samples are collected.


• 101 diversion of LC flow


Typically used to direct mobile eluent containing contaminants at a time point before the elution of the analyte of interest away from the LC–MS source. Usually a make-up mobile phase is directed to the LC–MS source while the eluent is diverted away in order to maintain instrument stability (e.g., avoid drying the curtain plate).


• 102 doping analysis


Laboratory procedures aimed at ascertaining the use of banned per- formance-enhancing substances and methods in sport by the analysis of biological fluids.


• 103 dosage regimen


The systematized schedule under which compounds are administered for


therapy; that is, the proper compound mass and proper time


interval between compound administration required to produce clinical effectiveness or to maintain a therapeutic concentration in the body.


• 104 dose–response curve


The graphical presentation of pharmacological response versus amount of compound administered (e.g., dose).


• 105 dosing interval The time period between multiple administrations of a compound.


S28


Bioanalysis (2016) 8(21) Suppl. 1


future science group


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