The Bioanalysis Glossary • 251 normal-phase chromatography


A type of chromatography employing a polar stationary phase and a nonpolar mobile phase. Hydrophobic analytes have limited affinity for the stationary phase and are eluted first, while hydrophilic analytes tend to adsorb to the stationary phase and are eluted by increasing the polarity of the mobile phase.


• 252 nuclear magnetic resonance (NMR) spectroscopy


Analytical technique that exploits the magnetic properties of some atomic nuclei to determine the physical and chemical properties of the atoms or molecules that contain them. Can provide highly detailed structural information and can be used both quantitatively and qualitatively.


• 253 oligonucleotide A short nucleic acid polymer, typically with less than twenty to thirty bases.


• 254 online extraction


A bioanalytical methodology that integrates sample extraction, typically in the solid-phase extraction format, and chromatography after injecting biological samples such as plasma with no or minimal pretreatment.


• 255 optimization


The process of varying the conditions of an analytical method to determine the optimal method conditions.


• 256 oral administration


Route of administration where a substance is taken through the mouth. This includes buccal, sublingual and prelingual administration routes.


S60


Bioanalysis (2016) 8(21) Suppl. 1


future science group


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