The Bioanalysis Glossary • 368 supercritical fluid chromatography (SFC)


Also known as "convergence chromatography", a chromatographic technique that employs a supercritical fluid as the mobile phase.


• 369 superficially porous (core-shell) particle technology


In LC columns, the use of particles that have a nonporous core but fully porous outer layer.


• 370 supernatant


The liquid layer resting above a lower layer or solid residue, such as after centrifugation following protein precipitation from plasma.


• 371 supported-liquid extraction


Sample extraction technique analogous to liquid–liquid extraction but with a different protocol that involves sample application to a solid support, composed of modified diatomaceous earth, and from which the analytes are subsequently eluted with water-immiscible organic solvent.


• 372 surface plasmon resonance (SPR)


Change of the reflective index of light reflected off a metallic film resulting from biomolecular binding on the opposite side of the film.


• 373 surrogate analyte


A compound similar to the analyte of interest used to evaluate extraction efficiency and matrix effects (e.g., stable-labeled isotope analogs).


• 374 surrogate matrix


Alternative matrix used in bioanalysis in place of an endogenous matrix that is difficult to sample, recreate or maintain.


S82


Bioanalysis (2016) 8(21) Suppl. 1


future science group


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