The Bioanalysis Glossary • 235 mobile phase


In chromatography, the mobile phase is a solvent (liquid, gas, supercrit- ical fluid) that moves through or along the stationary phase of a column resulting in movement of sample molecules. Separation of a mixture of analytes is achieved by differences in their inter actions between the mobile and stationary phases.


• 236 molecularly imprinted polymer (MIP)


An artificial affinity material consisting of a synthetic polymer, which is formed in the presence of a compound (the template), that is later removed and thus leaves specific binding sites or cavity for the template and structurally related molecules.


• 237 monolith


A solid support that consists of a single piece of porous material character- ized by a bimodal pore size distribution (macroporous and mesoporous), which confers favorable mass transfer properties, a large surface area and low pressure drops suitable for use in analytical or purification methods.


• 238 multi ascending dose (MAD; also known as ‘multiple ascending dose’)


A drug is given repeatedly at intervals shorter than those required to com- pletely eliminate the drug from the previously given dose. This dosing is used to study the pharmacokinetics (PK)/pharmacodynamics (PD) of multiple doses for safety and tolerability. The dose is increased over time to a predetermined maximal level.


• 239 multiple heartcutting 2D separation


In this mode of 2D-LC separation, several selected regions of the first separation are selected for further resolution by transferring the fluid exiting the first separation during several short (e.g., a few seconds to about a minute) intervals to the second separation column for further separation of sample constituents that were not initially separated by the first column.


S56


Bioanalysis (2016) 8(21) Suppl. 1


future science group


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