Terms & Definitions • 352 specimen


A specifically selected proportion of a material taken from a dynamic system and assumed to be representative of the parent material at the time it is taken. See also “sample”.


• 353 spike (noun)


A volume of solution containing reference item added to analytical matrix to define the concentration of known samples such as calibration standards and quality controls.


• 354 spike (verb)


The action of fortifying analytical matrix with a known concentration and volume of a reference item solution.


• 355 spike recovery


The amount of analyte that is measured upon analysis of a sample (e.g., matrix) to which a known amount of analyte has been added. See also “recovery”.


• 356 stability


The chemical stability of an analyte in a given matrix under specific conditions for given time intervals.


• 357 stable-labelled isotope


Analyte in which a few atoms are exchanged with heavy isotope counterparts, typically 2


H, 15 N or 13


standard in LC–MS bioanalysis as it has very similar physical and chemical properties as the analyte and works well to compensate for the variability due to extraction, chromatography and mass spectrometry (MS) detection.


C. It is commonly used as an internal


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