The Bioanalysis Glossary • 287 plasma protein binding


The extent to which a drug binds to endogenous plasma proteins, often expressed as the fraction of the drug that is protein-bound (in percentage).


• 288 point-of-care testing


Also known as ‘bedside testing’; bioanalytical testing near or at the site of patient care.


• 289 polymerase chain reaction (PCR)


A molecular biological method used to enzymatically amplify a single or few copies of a particular DNA sequence using short DNA sequences called DNA primers.


• 290 population-specific cut point


A threshold level determined for and applied to a target population to define the presence or absence of a response.


• 291 post-column infusion


Technique for the evaluation of matrix effect profiles in LC–MS analysis, by injection of a solvent blank or matrix blank into the chromatography column while simultaneously infusing analyte by a syringe pump to the column effluent.


• 292 post-translational modification (PTM)


Chemical modification to poly peptides, such as the attachment of functional groups (phosphate, carbohydrates), during their biosynthesis, but after their translation from the mRNA sequence.


S68


Bioanalysis (2016) 8(21) Suppl. 1


future science group


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