The Bioanalysis Glossary • 240 multiple-reaction monitoring (MRM)


A quantification strategy generally used in triple-quadrupole (QQQ) mass spectrometers in which an analyte ion with a particular mass-to- charge ratio (the precursor ion), most often corresponding to the intact ion of a target analyte is selected by a first quadrupole (Q1) in the mass spectrometer. The precursor ions is then subjected to collision-induced dissociation reaction with neutral gas, resulting in the formation of product ions, each with a particular mass-to-charge ratio, which are selected in another quadrupole (Q3) and are subsequently detected.


• 241 multiplexing


The ability of an analytical technique or device to process or analyze multiple samples simultaneously. This term also refers to the determination of multiple analytes using the same assay or run, such as a panel of biomarkers.


• 242 multi-site study Any study that has phases conducted at more than one site.


• 243 nanoflow


Nanoliter per minute flow rates employed in chromatographic separations with very narrow-bore capillary columns (≤500 nm i.d.).


• 244 nanofluid liquid chromatography


A liquid chromatographic method employing mobile phase flow at very low flow rates (nl/min).


• 245 neutralizing antibody (NAb)


An antibody that is formed in vivo in response to treatment with an antigen and that binds to a drug and blocks its function. For an enzyme drug, a neutralizing antibody would block its action on the substrate. For an agonist or antagonist drug, an antibody that blocks the drug binding to its ligand would neutralize the drug. Antibodies that bind to epitopes on a drug that do not affect the function of the drug are non-neutralizing antidrug antibodies.


S58 Bioanalysis (2016) 8(21) Suppl. 1 future science group


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