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was measured again on days 14 and 28. Using the regression-line function, the age that corresponds to the measured wrinkle depth was calculated. After 28 days of applying PROTEOLEA®
, individuals who averaged 44.4 years of age displayed
Perceivable skin rejuvenation 20 participants applied a test cream with 3% PROTEOLEA®
100 200 300 400 500
0 twice daily to the face, neck and
décolletage for four weeks and evaluated performance characteristics and effectiveness of the cream. PROTEOLEA®
received a very positive response
from the users: 100% felt that the cosmetic active conveys a pleasant skin feel, provides moisture and velvety softness all day long (not shown). More important, PROTEOLEA®
perceptibly counter-acted
the signs of time as a substantial number reported a visible rejuvenation effect. At the beginning of the study a minority of only 10% remarked that their skin looks younger than it actually is. At the end of the study, this number increased to 50% and as few as 5% were reporting that their skin is looking older than it is (Fig. 3).
391 500
Conclusion The Proteasome is an excellent cosmetic target to manipulate in order to maintain the pool of functional proteins and to prevent the accumulation of damaged proteins. We have shown here that proteasome
100 200
0 50%
Figure 2: Eye-wrinkle rejuvenation by 3.3 and 6.1 years within 14 and 28 days, respectively. Top: wrinkle depth was measured in four age groups (n=20 each), and a regression line was calculated to define age according to the wrinkle depth. Bottom: The age group 41–45 then applied a 3% PROTEOLEA®
RAHN AG, Stand D16
References 1. Friguet B et al. Protein degradation by the proteasome and its implications in aging. Ann N Y Acad Sci 2000,908:143-154.
2. Chondrogianni N et al. Proteasome activation as a novel anti-aging strategy. IUBMB Life 2008,60:651-655.
3. Farout L et al. Proteasome function in aging and oxidative stress: implications in protein maintenance failure. Antioxid Redox Signal 2006,8:205-216.
100%
4. Bregegere F et al. The ubiquitin-proteasome system at the crossroads of stress-response and ageing pathways: a handle for skin care? Ageing Res Rev 2006,5:60-90.
5. Katsiki M et al. The olive constituent oleuropein exhibits proteasome stimulatory properties in vitro and confers life span extension of human embryonic fibroblasts. Rejuvenation Res 2007,10:157-172.
0%
6. Mahajan RT. Phyto-Pharmacology of Ziziphus jujuba Mill- A plant review. Phcog Rev 2009,3:320-329.
gel twice daily, and wrinkle depth was
measured again on days 14 and 28. Using the regression-line function, the age that corresponds to the measured wrinkle depth was calculated
Figure 3: Perceivable skin rejuvenation. 20 test subjects assessed the perceived age of their skin at the beginning and the end. 9 of the 20 participants (= 45 %) reported a decrease in perceived age of the skin by at least one category
7. Kang SA. Levan: Applications and Perspectives. Caister Academic Press; 2009.
8. Jung T et al. Lipofuscin: formation, distribution, and metabolic consequences. Ann N Y Acad Sci 2007,1119:97-111.
a wrinkle depth that would be expected in subjects of 38.3 years. This equates to a rejuvenation effect of 6.1 years within only 28 days (Fig. 2, bottom).
activation may rejuvenate the skin by counteracting first signs of ageing, such as the formation of wrinkles around the eye area (crows-feet). Proteasome activation may also represent a very valuable approach to improve radiance and even skin tone by fading e.g. age spots. Age spots emerge upon accumulation of melanin and lipofuscin, a complex mixture of oxidised proteins and fat products, in epidermal keratinocytes [8]. Minimising the formation of these pigments by reactivating the proteasome and by blocking melanin biosynthesis will help to fade any brown skin blemish, whether it is a tan, freckle, or age spot.
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