Prochlorperzine is another dopamine-antagonist with significant anti-emetic properties. Common brand names are Stemetil and Promat. Marketed as 5mg tablets, a useful end of life regime is 2 tablets (10mg) taken an hour before the lethal medication. This drug readily crosses into the brain and has a propensity for sedation and extrapyramidal movement-related symptoms. These side effects can limit the drug’s usefulness and a test dose should be taken before considering this as your chosen end of life anti-emetic.
Ondansetron is also a very effective anti- emetic that acts as a seratonin antagonist. The most well known brand name is Zofran. Zofran
is most known for its use in controlling nausea associated with chemotherapy. This drug is marketed as 4mg or 8mg tablets. A suitable end of life regime is to take one or two tablets (4mg - 8mg) one hour before the lethal drug.
Ondanestron can have serious side effects, occasionally giving way to ‘seratonin syndrome’. This syndrome brings palpitations, flushing and agitation. Such side-effects may limit its use. In the absence of these side-effects, the dose can be increased to up to 5 tablets if nausea is a particular problem.