The propranolol is then quickly absorbed and interferes with the compensatory cardiac response to the effects of the methemoglobin produced by the nitrite. As the brain receives insufficient oxygen, a message is sent to the heart to increase blood flow. However, with propranolol present, the message is blocked and there is no increase in blood- flow to the brain. Consciousness is quickly lost.
The accompanying video shows how to create a nitrite/ propranolol mixture.
Note: Some reports mistakenly claim that acid reduction is counterproductive as it reduces [NO] release, hypotension and headache, and that B blockers provide only symptom relief and are an unnecessary 'luxury item'!
Note: Propranolol is usually prescription regulated, but it can be bought online. Slow-release forms of the drug are unsuitable.
Note: Earlier editions of the PPeH (and the included film) suggested using 2gm of Propranolol. This was altered to 800mg in April 2020.