The propranolol is then quickly absorbed and interferes with the compensatory cardiac response to the effects of the methemoglobin produced by the nitrite. As the brain received insufficient oxygen a message is sent to the heart to increase blood flow. However, with propranolol present, the message is blocked and with no increase in blood-flow to the brain, consciousness is quickly lost.
The accompanying video shows how to create the nitrite/ propranolol mixture.
Note: Some reports mistakenly claim that acid reduction is counterproductive as it reduces [NO] release, hypotension and headache, and that B blockers provide only symptom relief and are an unnecessary “luxury item”!
Note: Propranolol is usually prescription regulated, but it can readily be bought on-line. Slow release forms of the drug are unsuitable.
Note: Earlier editions of the PPeH (and the included film) suggested using 2gm of propranolol. This was altered to 400mg in Feb 2021.