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Supplements & functional ingredients


The medical benefits of Due to the potentially crucial role of vitamin K2 in calcium metabolism, a


defi cit can disrupt many mechanisms and result in an array of health issues. The potential of vitamin K2 as a treatment for conditions, including cerebral palsy, parathyroid disease, heart disease and gastrointestinal disease, is uncertain. Ingredients Insight presents an edited extract from ‘The Medical Benefi ts of Vitamin K2 on Calcium-Related Disorders’ by Zeyad Khalil, Benjamin Alam, Amir Reza Akbari and Harbans Sharma of the University of Manchester, investigating the biochemistry of vitamin K.


vitamin K2 V


itamin K has undergone comprehensive research over a long period, revealing its array of medicinal properties that prove beneficial for use in the medical community. Data indicates that vitamin K2 has a positive impact on osteoporosis, cardiovascular disease, parathyroid disorders, cerebral palsy and sperm motility. It was first discovered by Henrik Dam in 1935; through experimenting the regimens of chickens and interchanging various sources of their diets, Dam isolated this compound and named it after the German word for coagulation. The chickens showed a decrease in haemorrhages when given regimens with the vitamin, and this was


30


a defining moment that sparked further research into vitamin K.


Following the initial identification, it was soon established that there are multiple types of vitamin K – divided from one to five. The two major subtypes are vitamin K1 and K2, whereas the vitamin K3 is a synthetic form that can be converted to vitamin K2 in vivo. Conversely, vitamin K1 and K2 are both fat- soluble, allowing them to enter cells without the need of transmembrane transport proteins, particularly in animals – while K3 is water-soluble. It has been hypothesised that vitamin K2 is just as significant in effect as K1, owing to the differing


Ingredients Insight / www.ingredients-insight.com


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