FACILITY UPGRADES
hazardous materials. After considering the hospital’s risk assessment and proposed operating procedures, our team designed the airflow to minimise contamination risk while ensuring that accidental spillages in the ATMP isolator room are contained. By maintaining highest negative pressure in the second stage change room, the facility will ensure any spillage in the isolator room cannot escape to the inner support or first stage change areas, nor even to the outer support area. The CT areas will be accessed from the
opposite end of the same central corridor, with a similar route through the outer support room to a Grade D first change area into the Grade D inner support room. From here, operatives will enter the Grade C second change area before accessing the Grade C isolator room. These facilities will also be built with traffic-light managed air lock system between each controlled environment. Pressure regimes will be the same differentials as implemented in the new pharmacy. The air handling provision will follow the model already constructed for the new pharmacy, with full fresh air supply via the AHUs and a HEPA-filtered air extract, along with individual HEPA- filtered exhausts for each isolator.
Clean and controlled environment To retain a functioning pharmacy at all times, two air handling units were installed as part of the phase one programme. The fresh air supply will serve both the classified clean room areas and the ancillary rooms and HEPA filters will clean the extracted air before this is released into the atmosphere. In addition to the general extract,
Local Extract Ventilation (LEV) exhaust systems have been designed into the facility where sporicidal and alcohol spraying occur, with the CT and ATMP isolator room LEVs being filtered through safe change HEPA units before being discharged to atmosphere. Across all cleanroom-classified areas
of the new chemotherapy aseptic suite and CT/ATMP aseptic facilities, the environment will have a strict temperature control tolerance, as well as upper humidity limits for occupier comfort. The Grade C areas will be maintained at 19˚C±±2˚C while the Grade D rooms are maintained at 19.5˚C±±1.5˚C, and both areas have an upper limit of 55 per cent relative humidity. To ensure that these conditions are
met consistently, a new BMS (building management system) has been installed specifically for the chemotherapy aseptic suite and CT/ATMP aseptic facilities. This will constantly monitor temperature, humidity and the various air pressure cascades between the different grades (C, D and CNC+) of the rooms. Temperature sensors installed in the return ductwork
IFHE DIGEST 2022
A dedicated air handling system has been installed to support the facility.
from each room will monitor the temperature of the air leaving the location, enabling automated temperature adjustments by the BMS in line with real time conditions. In this way, the environment will consistently meet temperature and humidity parameters, regardless of occupancy levels, equipment use or outdoor temperatures.
Ease of maintenance The logistical and maintenance implications of AHU specification were also integral to the design process. Often facilities of this kind are specified with some level of redundancy in the AHU installation as standby provision for the controlled environment. The challenges of locating additional standby AHU capacity in the limited seventh floor plant room location, however, led to an alternative approach. Fault monitoring has been built into the BMS to ensure fans are repaired or filters are changed before a developing fault can begin to affect the performance of the air handling system. Indeed, ease of maintenance and the
need to ensure the environment remains fit for purpose has influenced all aspects of the design, including the choice of materials and finishes. The inner support and isolator areas are fully vinylled across the walls, floors and ceilings creating a robust and easy to clean environment with no crevices where particles can collect. All work benches and desks have been fabricated using Corian – a smooth impervious material that is compatible with cleaning agents and regimes. The workstations and benches have smooth rounded edges to ensure there are no awkward corners, with every effort made to enable faster, easier and more effective cleaning.
Commissioning and validation Validation of the new facilities has been embedded in the project design and construction process from the outset. Design reviews commissioned by the Trust were documented to enable design qualification, which considers the validity of the design against the URS and compliance requirements.
Further detailed documentation has also been compiled by our team during the construction phase to ensure the installation qualification carried out by the hospital Trust cross-references with the as-built information, the detailed design and the URS. We are also responsible for commissioning the new facilities and ensuring accurate information is available for future maintenance or modifications. Operational and performance qualification of the facilities will be undertaken by the hospital’s chemotherapy aseptic dispensing team, following completion of each build phase. We also carried out airborne particle cleanliness classification tests, recovery (clean up) tests and airflow (smoke) visualisation studies. All validation requirements were built into to the design and construction process at every stage, reducing validation risk and ensuring the availability of all design, installation and compliance documentation.
Pioneering facilities The co-ordination of architectural design, building services engineering and construction across the interdisciplinary BES team will result a best in class facility that supports the hospital’s reputation for excellence in cancer treatment and creates a template for future gene therapy preparation facilities for other NHS Trusts.
IFHE 95
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48 |
Page 49 |
Page 50 |
Page 51 |
Page 52 |
Page 53 |
Page 54 |
Page 55 |
Page 56 |
Page 57 |
Page 58 |
Page 59 |
Page 60 |
Page 61 |
Page 62 |
Page 63 |
Page 64 |
Page 65 |
Page 66 |
Page 67 |
Page 68 |
Page 69 |
Page 70 |
Page 71 |
Page 72 |
Page 73 |
Page 74 |
Page 75 |
Page 76 |
Page 77 |
Page 78 |
Page 79 |
Page 80 |
Page 81 |
Page 82 |
Page 83 |
Page 84 |
Page 85 |
Page 86 |
Page 87 |
Page 88 |
Page 89 |
Page 90 |
Page 91 |
Page 92 |
Page 93 |
Page 94 |
Page 95 |
Page 96 |
Page 97 |
Page 98 |
Page 99 |
Page 100 |
Page 101 |
Page 102 |
Page 103 |
Page 104 |
Page 105 |
Page 106 |
Page 107 |
Page 108 |
Page 109 |
Page 110 |
Page 111 |
Page 112 |
Page 113 |
Page 114 |
Page 115 |
Page 116