48 ANTI-AGEING
Figure 3: Immunodetection of CRABP2 in Asian skin biopsies treated with 1% rosewood extract for 48 hours
Figure 4: Visioline VL650 showing smoother fine lines and improved appearance of wrinkles (crow’s feet area) in Asian study participants fgene.2018.00462
Results on Caucasian study participants
showed redefined facial contours with fuller cheekbones and less visible smile lines on Caucasian skin after 28 and 56 days (Figure 5). The rosewood extract demonstrated
clinically proven benefits on cheekbones volume, V shape line, skin bounciness, smile lines and skin elasticity and smoothness.
Conclusion Liftyl™ biofunctional is a rosewood extract designed to increase key influential markers involved in face sculpting, following ethno- genomic research in facial morphology and face sculpting. It is associated with seven visible skin benefits clinically proven on Asian and Caucasian study participants: lifted face contours, lifted V shape line, increased skin firmness, softer and fuller smile lines, softer fine lines and crow’s feet, fuller cheekbones, improved facial harmony.
2. Xiong Z, Dankova G, Howe LJ et al. Novel genetic loci affecting facial shape variation in humans. eLife. 2019;8:e49898. doi:10.7554/ eLife.49898
3. White JD, Indencleef K, Naqvi S et al. Insights into the genetic architecture of the human face. Nat. Genet. 2021;53(1):45-53. doi:10.1038/s41588-020-00741-7
4. Berry MA, Linoff GS. Mastering Data Mining: The Art and Science of Customer Relationship. Industrial Management & Data. July 2000
5. Mukherjee S, Date A, Patravale V, Korting HC, Roeder A, Weindl G. Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clin. Interv. Aging. 2006;1(4):327-348. doi:10.2147/ ciia.2006.1.4.327
PC
References 1. Richmond S, Howe LJ, Lewis S, Stergiakouli E, Zhurov A. Facial Genetics: A Brief Overview. Front. Genet. 2018;9:462. doi:10.3389/
EVALUATION OF JAWLINE SAGGING VOLUME D28-D0
40 20 0
-20 -40
■ Placebo treated group ■ 1% RW treated group Figure 5: Decrease in jawline sagging volume in Caucasian study participants PERSONAL CARE July 2023
www.personalcaremagazine.com
-230% **
D56-D0
-155% *
6. Raja E, Changarathil G, Oinam L et al. The extracellular matrix fibulin 7 maintains epidermal stem cell heterogeneity during skin aging. EMBO Rep. 2022;23(12):e55478. doi:10.15252/embr.202255478
7. Liu Y, Ho C, Wen D et al. Targeting the stem cell niche: role of Collagen XVII in skin aging and
wound repair. Theranostics. 2022;12(15):6446- 6454. doi:10.7150/thno.78016
8. Xiang Y et al. Reduced expression of Collagen 17A1 in naturally aged, photoaged, and UV- irradiated human skin in vivo: Potential links to epidermal aging. J. Cell Commun. Signal. 2022 Sep; 16(3): 421–432. doi: 10.1007/ s12079-021-00654-y
9. Watanabe M, Natsuga K, Nishie Wet al. Type XVII Collagen coordinates proliferation in the interfollicular epidermis. ELife. 2017;6:e26635. doi:10.7554/eLife.26635
10. Okuno R, Inoue Y, Hasebe Y et al. Genome- wide association studies in Japanese women identified genetic loci associated with wrinkles and sagging. Exp. Dermatol. 2022;31(9):1411-1420. doi:10.1111/exd.14612
11. Martin MJ, Estravís M, García-Sánchez A, Dávila I, Isidoro-García M, Sanz C. Genetics and Epigenetics of Atopic Dermatitis: An Updated Systematic Review. Genes. 2020;11(4):442. doi:10.3390/genes11040442
12. Bielli A, Scioli MG, D’Amico F et al. Cellular retinoic acid binding protein-II expression and its potential role in skin aging. Aging. 2019;11(6):1619-1632. doi:10.18632/aging.101813
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