SKIN CARE A 150 100 50 0 16.3 B Placebo


Microcurrent device


Placebo


2% Uplevity e-Lift peptide solution


2% Uplevity e-Lift peptide solution


250 200 150 100 50 0


23


94.6


Placebo 2% Uplevity e-Lift peptide solution


Microcurrent device


2% Uplevity e-Lift peptide solution


Placebo


Female volunteer 13, 55 years old


Female volunteer 28, 54 years old


Figure 9: A) Percentage of crow´s feet lifting effect vs. placebo cream (upper panel) and representative images showing the crow´s feet lifting effect (lower panel). Red arrows correspond with a skin movement higher than 1.5mm. B) Percentage upper cheek lifting effect vs. placebo cream (upper panel) and representative images showing the crow´s feet lifting effect (lower panel). Red arrows correspond to skin movement greater than 1.5mm


position induced by the treatment. As seen in Figure 6C, the eyebrow was at a higher position after 28 days of active cream treatment (red) versus initial time (green). Next, we quantified the eyelid lifting effect.


This was measured from 2D images generated by Framescan, where the distance between the base of the eyelashes to the upper eyelid fold was measured. The longer the distance, the more lifted the upper eyelid. A cream containing 2% of the novel


peptide solution improved the eyelid lift by 6.1% in a statistically significant manner, when compared to initial time, and even better performance than the group using the microcurrent device (Figure 7). Finally, the lifting of the crow´s feet and


upper cheek regions were calculated from facial 3D images obtained with Quantificare LifeViz software, coupled with proprietary Lubrizol computer vision techniques. Using the Quantificare LifeViz software, firstly the 3D images from the initial and final time points were overlapped. Then, the software created facial images


with arrows on the skin surface, which represented the direction and amount of the skin movement between times of measurements (Figure 8A). However, this approach does not generate


an average value for the lifting effect. To solve this, the Lubrizol R&D team developed a proprietary computer vision technique. It performed 3D imaging processing data analysis and detected and quantified almost 7,000 arrows from the images obtained in the facial areas of interest.


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INFO@CARIBNATURALPRODUCT.COM February 2024 PERSONAL CARE Sun Care


Crow's feet lifting effect (%)


Crow's feet lifting effect (%)


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