53 Temperature Controlled Stages Help Researchers to Advance the Knowledge of Pharmaceutical Processes
Linkam Scientific Instruments (UK) report on the use of their stages in the study of pharmaceutical processes at the Robert Gordon University, Scotland. The School of Pharmacy and Life Sciences at the Robert Gordon University have been using Linkam systems to look at the behaviour of drugs at varying temperatures. This relatively young university was awarded with the prestigious ‘The Sunday Times Best Modern University in the UK’ in 2012 with the School of Pharmacy and Life Sciences being one of the key factors contributing to this recognition.
Dr Kerr Mathews, a lecturer in Pharmaceutics at the University since 2004, has focused a lot of time and effort in key interests in the area of drug delivery and formulation science. In particular, the research and development of solid and liquid drug delivery systems have been extensively undertaken.
Dr Matthews has used both a Linkam LTS stage and a FDCS stage to study the phase transitions of drugs, excipients and delivery systems as a function of temperature. He has found the equipment to be integral to his work. “We find this classic technique of qualitative analysis invaluable when used in conjunction with differential scanning calorimetry (DSC) or thermogravimetry (TGA), especially to corroborate assignment of phase transitions in solids or liquids.”
He added that the ability to study the samples under polarised light is also of vital importance. “We also use the capabilities of a materials microscope fitted with cross-polarising filters in both transmitted and reflected light modes, to assess the degree of anisotropy in solid solutions, polymers and assorted dosage forms.”
Lyophilisation is another application that is of particular interest to Dr. Matthews and his team. They have used the Linkam FDCS 196 stage to recreate low temperature conditions which are encountered during the pharmaceutical freeze drying process.
With the ever increasing cost of pharmaceutical products, the importance of research into the formulation and stability of drugs has never been higher. World renowned companies from all over the globe use such research to optimise the synthesis and storage of their products.
28786pr@reply-direct.com The Perfect All-Purpose Mill for Rapid Comminution
The Fritsch Variable Speed Rotor Mill PULVERISETTE 14 grinds rapid and effectively soft to medium-hard, brittle as well as fibrous samples. Even the comminution of samples which are difficult to grind or temperature-sensitive samples like tablets, dragées and pharmaceuticals are no problem for the PULVERISETTE 14 due to its very efficient air cooling.
In addition to the special air cooling of the PULVERISETTE 14, Fritsch-impact blades have developed: a clever design which allows, together with a sieve ring, very gentle grinding of the sample, which in many cases without impact blades would not be possible. This results in increased grinding action for particularly fast and effective grinding as well as minimised heat load. The PULVERISETTE 14 is the ideal solution for especially temperature-sensitive materials such as powder coatings or plastics, as well as for smoothly pre- and fine grinding of hard-brittle to soft, fatty sample or samples with a residual moisture.
The Variable Speed Rotor Mill PULVERISETTE 14 has a top speed of 20.000 rpm and is the turbo mill for sample preparation. With a feed particle size of < 10 mm, a final fineness of up to 40 µm can be achieved. The throughput depends on the material and lies between 0.05 and 5 litres per hour. Rotors, sieve rings and collecting vessels made of different materials and in different sizes enable an optimal adjustment of the instrument to the application.
Further advantages include: simple and easy change of all grinding parts without tools; simple, contamination-free cleaning and assembly of all grinding parts outside the instrument; variable speed adjustment from 6,000 to 20,000 rpm; automatic speed following system for constant grinding; grinding parts made of stainless steel, pure titanium, TiN-coated and WC-coated; rapid-action clamping lock.
28894pr@reply-direct.com Powerful Evaporator for Drug Discovery
The HT-4X centrifugal evaporator from Genevac provides optimised sample preparation capabilities for scientists working in the drug discovery environment. Built to the highest specifications, the HT-4X makes demanding applications routine. Corrosive vapours such as trifluoroacetic acid may be removed by the standard system and an inert purge option allows high safety evaporation of flammable solvents. In addition, the HT-4X can also be used to achieve high speed lyophilisation of HPLC fractions and solvents used for reformatting samples.
The HT-4X is a high performance evaporator that combines ease of use, compactness, operational versatility and efficient sample processing. An innovative built-in dual chamber refrigerated condenser, that combines a powerful cryopump and solvent recovery system, together with extra powerful IR lamps, accelerates the speed of evaporation, even for high boiling point solvents such as DMSO. In addition, efficient chamber cooling between runs is particularly useful to protect thermally sensitive samples when run immediately after higher boiling point solvents. The system additionally offers an auto-defrosting condenser option and novel functions such as auto shutdown and auto-solvent selection, making it extremely easy to use. Genevac’s patented SampleGuard™ and Dri-Pure® technology is included to protect samples from overheating and bumping.
Operated via an integral full colour screen the Genevac HT-4X offers comprehensive display of real-time data enabling rapid methods development across a wide range of applications. The easy-to-use system provides facility to store up to 99 evaporation methods making it ideal for multi-user environments.
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HPLC Column Separates Wide Variety of Pharmaceutical Counterions
Thermo Fisher Scientific is pleased to announce the expansion of the Acclaim™ Trinity™ family of HPLC column with new Acclaim Trinity P2 columns. The new columns are designed to screen a wide range of counterions, including cations, anions, mono and multi-valent ions with one analysis, thanks to advanced mixed-mode Nanopolymer Silica Hybrid (NSH™) technology. Simple LC screening of the Active Pharmaceutical Ingredients (API) and their counterions can be achieved with high sensitivity using the Thermo Scientific™ Dionex™ Corona™ Charged Aerosol Detector. The chemistry is designed to provide spatial separation of the anion exchange and cation regions, resulting in greater resolution and selectivity control. Also, the particles’ hydrophilic surface makes the Acclaim Trinity P2 useful as a HILIC column. It provides cation exchange, anion exchange and HILIC retentions on the same stationery phase, helping customers develop robust, fast, generic methods to improve productivity and reduce cost.
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