a published medical paper coined the term “type III diabetes” as another way to consider Alzheimer’s. In 2008, a scientific review concluded that there was, “strong evidence in support of the hypothesis that Alzheimer’s disease represents a form of diabetes mellitus that selectively afflicts the brain…containing molecular and biochem- ical features that overlap with both type I and type II diabetes mellitus.” Understand- ing this connection is imperative in consid- ering beneficial prevention strategies.
Higher and higher levels of glucose in the blood stimulate the body to produce more and more insulin. Elevated insu- lin levels have direct negative effects on multiple regions of the brain, including increasing oxidative stress, damaging pro- teins, and increasing inflammation, leading to higher expression of amyloid protein formation. Since the pathological changes within the body (including the brain) secondary to elevated blood sugar levels are relatively slow in progression, we must consider preventative interventions much earlier in life to reduce risk of the develop- ment of Alzheimer’s disease. Fortunately, much is known about interventions for the prevention of type II diabetes, and many of these recommendations are applicable in the case of Alzheimer’s disease.
Dietary Interventions in Alzheimer’s Prevention
Primarily, it is important to consider
where all this excess glucose comes from. In the vast majority of cases it comes from our diet, of course! It should come as no surprise that what we choose to eat day in and day out, week after week, month after month, year after year, is probably the most important thing to consider when it comes to Alzheimer’s disease prevention. Fortu- nately, the dietary recommendations here are not all that dissimilar to those suggested for other common chronic diseases, includ- ing cardiovascular disease and diabetes. What is good for the heart is also good for the brain.
Dietary recommendations can unfor- tunately be quite confusing, with someone always coming up with the latest and great- est way to eat. Through all the fads, the Mediterranean diet has withstood the test of time, with innumerable studies showing its benefit in the prevention of a wide range of inflammatory conditions, ranging from Parkinson’s disease to cancer, heart attack and stroke. This way of eating, which is rich in fish, vegetables, fruits, nuts and olive oil, has been proven to be beneficial for the
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