Drugs are generally converted to biologically inactive forms and eliminated from the body, principally by hepatic metabolism. However, certain drugs undergo biotransformation to reactive metabolites that can interfere with cellular functions. These are often electrophilic and can interact with DNA and proteins to form covalently bound products.
• 351 reanalysis
Repetition of a series of analytical procedures, from the processing step onwards, on samples that have been previously analyzed.
• 352 recovery (extraction)
The extraction efficiency of an analytical process, reported as a percentage of the known amount of an analyte carried through the sample extraction and processing steps of the method.