Terms & Definitions • 303 per aqueous liquid chromatography


Chromatographic mode that is a variant of reversed-phase, manifesting typically on unmodified silica at typically 80 to 100% aqueous mobile phases via surface siloxane moieties and highly energetic adsorptive sites on the silica surface.


• 304 peripheral compartment


The sum of all body regions to which a drug eventually distributes, but are less perfused and therefore are not in instantaneous equilibrium with the concentration in blood or plasma.


• 305 pharmacodynamics (PD)


The relationship between drug concentration at the site of action (receptor) and pharmacologic response, including biochemical and physiologic effects that influence the interaction of drug with the receptor.


• 306 pharmacokinetics (PK)


The kinetics of drug absorption, distribution, and elimination (i.e., excretion and metabolism). Distribution occurs not only to site of action, but to multiple other tissues in the body.


Sponsored by • 307 pharmacometabonomics/pharmacometabolomics


Analysis of endogenous metabolites in bodily fluids used to predict or evaluate the metabolism of pharmaceutical drugs, and to understand the pharmaco kinetic profile of a drug. Alternatively, it is applied to measure metabolite levels following the administration of a pharmaceutical drug, in order to monitor the effects of the compound on certain biochemical pathways.


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