The Bioanalysis Glossary • 99 curvature


Within linear regression, the manifestation of a nonlinear (i.e., curvilinear) response versus concentration profile within a given concentration range for a quantitative bioanalytical method. From a statistical approach, curvature is the rate at which the slope changes. It is the second derivative of any function; for a straight line, the second derivative is ‘0’, for a quadratic regression model (also a linear function), the rate is positive or negative.


• 100 cut point


The value at, or above, which instrument response is considered positive and below which response is considered negative (in an antidrug antibody/ imunogenicity assay).


• 101 cytochrome P450


A superfamily of heme-containing enzymes that can metabolize a variety of compounds via multiple pathways.


• 102 daughter ion


An electrically charged product of the reaction of a particular parent ion in mass spectrometry. Typically, occurs in mass spectrometric analysis in the collision quadrupole as the result of high-energy interactions between the analyte and carrier gas. Also known as "product ion".


• 103 deconvolution


In the context of biomolecule mass spectra, charge deconvolution is a program or algorithm that identifies peaks associated with different charge states for given molecular entities, and combines these into simplified spectra involving only mass (not m/z) and response. Deconvolution may also be applied to deal with peaks arising from isotopic distributions in the same kinds of molecules, in a process called deisotoping.


S30


Bioanalysis (2018) 10(21) Suppl. 1


future science group


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