The Bioanalysis Glossary • 265 multiple-reaction monitoring (MRM)


A quantification strategy generally used in triple-quadrupole (QQQ) mass spectrometers in which an analyte ion with a particular mass-to- charge ratio (the precursor ion), most often corresponding to the intact ion of a target analyte is selected by a first quadrupole (Q1) in the mass spectrometer. The precursor ions is then subjected to collision-induced dissociation reaction with neutral gas, resulting in the formation of product ions, each with a particular mass-to-charge ratio, which are selected in another quadrupole (Q3) and are subsequently detected.


• 266 multiplexing


The ability of an analytical technique or device to process or analyze multiple analytes in a sample in parallel. This term also refers to the determination of multiple analytes using the same assay or run, such as a panel of biomarkers.


• 267 multi-analyte


Pertains to a methodology that has more than one analyte, each of which will be subject to any appropriate acceptance criteria.


• 268 multi-site study Any study that has phases conducted at more than one site.


• 269 nanoflow


Nanoliter per minute flow rates employed in chromatographic separations with very narrow-bore capillary columns (≤500 nm i.d.).


• 270 nanofluid liquid chromatography


A liquid chromatographic method employing mobile phase flow at very low flow rates (nl/min).


S68


Bioanalysis (2018) 10(21) Suppl. 1


future science group


Page 1  |  Page 2  |  Page 3  |  Page 4  |  Page 5  |  Page 6  |  Page 7  |  Page 8  |  Page 9  |  Page 10  |  Page 11  |  Page 12  |  Page 13  |  Page 14  |  Page 15  |  Page 16  |  Page 17  |  Page 18  |  Page 19  |  Page 20  |  Page 21  |  Page 22  |  Page 23  |  Page 24  |  Page 25  |  Page 26  |  Page 27  |  Page 28  |  Page 29  |  Page 30  |  Page 31  |  Page 32  |  Page 33  |  Page 34  |  Page 35  |  Page 36  |  Page 37  |  Page 38  |  Page 39  |  Page 40  |  Page 41  |  Page 42  |  Page 43  |  Page 44  |  Page 45  |  Page 46  |  Page 47  |  Page 48  |  Page 49  |  Page 50  |  Page 51  |  Page 52  |  Page 53  |  Page 54  |  Page 55  |  Page 56  |  Page 57  |  Page 58  |  Page 59  |  Page 60  |  Page 61  |  Page 62  |  Page 63  |  Page 64  |  Page 65  |  Page 66  |  Page 67  |  Page 68  |  Page 69  |  Page 70  |  Page 71  |  Page 72  |  Page 73  |  Page 74  |  Page 75  |  Page 76  |  Page 77  |  Page 78  |  Page 79  |  Page 80  |  Page 81  |  Page 82  |  Page 83  |  Page 84  |  Page 85  |  Page 86  |  Page 87  |  Page 88  |  Page 89  |  Page 90  |  Page 91  |  Page 92  |  Page 93  |  Page 94  |  Page 95  |  Page 96  |  Page 97  |  Page 98  |  Page 99  |  Page 100  |  Page 101  |  Page 102  |  Page 103  |  Page 104  |  Page 105  |  Page 106  |  Page 107  |  Page 108  |  Page 109  |  Page 110  |  Page 111  |  Page 112  |  Page 113  |  Page 114  |  Page 115  |  Page 116  |  Page 117  |  Page 118  |  Page 119  |  Page 120  |  Page 121  |  Page 122  |  Page 123  |  Page 124  |  Page 125  |  Page 126  |  Page 127  |  Page 128  |  Page 129  |  Page 130  |  Page 131  |  Page 132  |  Page 133  |  Page 134  |  Page 135  |  Page 136