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The Bioanalysis Glossary • 216 ligand-binding assay (LBA)


Quantitative method based on the binding of ligand molecules to antibodies or receptors, typically used for biomolecules where the reliance is on highly specific epitope–paratope interactions between antigen and antibody.


Sponsored by • 217 limit of detection (LOD)


The lowest concentration of an analyte that a bioanalytical procedure can reliably differentiate from background noise (e.g., “detected and not quantified”).


• 218 linear regression


An approach for modeling the linear relationship between analyte concentration and instrument response (typically the ratio between analyte and internal standard).


• 219 lipidomics


A comprehensive measure of all the lipophilic species present in a given sample typically employing liquid chromatography coupled to tandem mass spectrometry and high resolution mass spectrometry.


• 220 liquid chromatography (LC)


Chromatographic technique that employs a liquid mobile phase, a liquid sample injected, and a packed column stationary phase of appropriate chemistry for the required selectivity. This technique can be coupled to a variety of detectors, most notably mass spectrometry for bioanalysis.


Terms & Definitions


S56


Bioanalysis (2018) 10(21) Suppl. 1


future science group


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