%bias = mean measured conc. - nominal conc. nominal conc.
• 3 %CV
%CV = standard deviation (SD) mean measured conc. × 100
• 4 %recovery %recovery = 100 × mean
peak area ratio (extracted samples) peak area ratio (post-extraction spiked samples)
Note: a ratio of means is different from a mean of ratios • 5 bioavailability
AUC (administration via way X AUC (intravenous administration)
Where: AUC typically refers to plasma AUC AUC-intravascular refers to the plasma AUC obtained after intravenous drug administration and AUC-extravascular refers to the plasma AUC obtained after administration by a route other than intravenous administration.
