Terms & Definitions • 291 parallelism
A condition in which dilution of test samples does not result in biased measurements of the analyte concentration. Determined for immuno- assays by comparison of the responses from the calibration standard curve
and serially diluted study samples in order to detect possible matrix effect or differing affinities for metabolites
• 292 paratope The part of an antibody that recognizes an antigen.
• 293 partial least squares regression (PLS)
Well-established regression-based method thanks to its ability to deal with many correlated variables or in situations where fewer observations than measured variables are available. PLS builds a low-dimensional sub-space by maximizing the covariance between the data and the class assignment. Orthogonal partial least squares analysis (O-PLS) and O2-PLS are recent extensions of the PLS method applied to many fields, such as for metabolomic data.
• 294 partial validation
Series of analytical experiments where only relevant parts of the validation are repeated after method modifications or transfer of an existing fully validated bioanalytical method.
• 295 peak area
The area of the peak on a chromatogram produced by a substance subjected to chromatographic analysis. Proportional to either the concentration or mass of the substance, depending on the mode of detection.
• 296 peak area ratio
Ratio of the instrument response peak area of the target compound in the sample to the peak area of an internal standard.
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