The Bioanalysis Glossary
• 275 non-zero calibrator A calibrator to which the IS is added.
• 276 nonspecific adsorption/binding
Undesirable phenomenon of the chemical adsorption of solvated analytes to the interior surfaces of the vessels containing the solution. Typically addressed by the use of a solvent composition within which the given analyte has increased or free solubility at the appropriate concentrations, and/or the use of vessels of different material or surface chemistry.
• 277 nontargeted analysis
Analysis of the composition of a complex sample without applying predefined selection criteria, with the aim to identify previously unknown sample components. The opposite of selective (targeted) analysis in which specific data are generated.
• 278 normal-phase chromatography
A mode of chromatography employing a polar stationary phase (e.g., native silica) and a nonpolar mobile phase. Lipophobic analytes have limited affinity for the stationary phase and are eluted first, while hydrophilic analytes tend to adsorb to the stationary phase and are eluted by increasing the polarity of the mobile phase.
• 279 nuclear magnetic resonance (NMR) spectroscopy
Analytical technique that exploits the magnetic properties of some atomic nuclei to determine the physical and chemical properties of the atoms or molecules that contain them. Can provide highly detailed structural information and can be used both quantitatively and qualitatively.
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Bioanalysis (2018) 10(21) Suppl. 1
future science group
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