From basic compound to high market value product
StratiCELL is a project-driven service provider for in vitrotesting of skin care ingredients and finished products
Prior to in vivoassessment on human volunteers and as an alternative to animal testing, in vitromodels and laboratory testing services provide relevant and reliable biological information in order to bring a strong scientific added- value to a product, such as characterisation of activities and safety evaluations or mechanistic data. This added-value to products supports decision making processes in the research and development and/or marketing phase.
Assisting the cosmetic industries in the efficacy evaluation of their actives and products by means of in vitromodels and methods is key. Continuously developing methods and models to address and support new and innovative claims is also very important.
StratiCELL, as a project driven skin model manufacturer and service provider for in vitrotesting, puts particular emphasis on the testing of skin care actives and products:
Discovering new targets and identifying mechanisms of action StratiCELL offers an integrated service for gene expression screening from single gene analysis to whole transcriptome profiling. This is a powerful way to discover targets and innovative skin care benefits.
Gene expression profiling on selected gene sets is based on real-time RT-PCR in medium-throughput format (384-well plates, also called TaqMan arrays). With this technology, up to 384 selected genes involved in some key skin biology processes can be analysed and quantified simultaneously. Besides the 384 genes array, StratiCELL predefined TaqMan arrays focused on 48 and 96 genes involved in specific thematic as dermal remodeling, pigmentation, epidermal biology, etc.
Whole transcriptome gene profiling is based on Affymetrix DNA microarrays. DNA microarrays enable to monitor the expression profile from the whole transcriptome to provide deeper insights to product signatures. This technology is key to identify and characterise a large number of genes or pathways that are either up-regulated or down-regulated in basal or challenge conditions and that could be modulated or reversed by the test product.
Tissue engineering and customised models and methods With strong expertise in skin biology and tissue engineering, StratiCELL develops custom-made models and assays. For instance, StratiCELL has recently produced a skin model that mimics atopic dermatitis (initiation, immune system activation and epidermal barrier perturbation)
Supporting skin care benefits through scientific data Skin care benefit endpoints include anti-ageing and detoxification, sun protection, skin whitening and pigmentation, barrier function and epidermal homeostasis, dermal cohesion and structure, anti-inflammation and calming, re-epithelialization and wound healing, etc.
Dermal safety
Safety testing endpoints include in vitromethods for cytotoxicity, dermal toxicity (OECD 439 and 431), eye irritation (using corneal epithelia), skin absorption (OECD 428) etc.
Bioavailability through formulation StratiCELL offers reliable and accurate in vitromethods for the determination of percutaneous penetration and absorption of active compounds. The purposes of the assay are the kinetic measurement of penetration through the skin, the measurement of absorption into the skin layers and the benchmark of different compound formulations, vectorizations, encapsulations, etc. Analytical analysis is in StratiCELL’s hands using HPLC method coupled to mass spectrometry.
StratiCELL SA/NV, Stand 4J31
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