STAFF SAFETY
Architectural design
The architectural design development for the new production facility drew on the long-standing relationship between AstraZeneca and BES, with knowledge of previous projects delivered on the same campus feeding into an understanding of how the spatial layout of the new building would complement working practices and output requirements.
While workflows are vital to the efficiency of a facility of this kind and influenced by the complex processing stages involved in production, the size of the equipment was a major factor in determining the layout. The positioning of these key pieces of kit was largely determined by where each process sits in the production journey and this central element of the layout then influenced spatial planning due to the HVAC, electrical specification and maintenance demands of each area. The inter-disciplinary team provided by BES meant that the technical elements and
spatial, process and workflow requirements of the architectural design could be considered as part of a fully-integrated approach, ensuring any buildability issues that might arise from the building services specification were engineered out of the architectural design long before the project was on site. For example, the client’s focus on creating as much visibility as possible of the cleanroom and sterile production areas within the building had a considerable impact on ducting routes, and sizes; ultimately influencing the thickness of the internal walls. The concept was for large windows built into the internal walls to enable operatives to view processes in the clean and sterile areas without having to follow the time consuming clean room washing and gowning protocols required to actually enter the space. However, due to the amount of airflow required for the HVAC and air handling equipment this, user requirement created an issue with routing the ductwork for the clean and sterile areas around the glazed panels in the walls. The solution was to increase the thickness of the walls to enable the use of narrower ductwork while keeping the same air flow capacity with increased depth. This change to the wall thickness reduced the internal area of the affected rooms so the design team had to ensure there was sufficient flexibility in the footprint of each room for its designated process equipment, building services plant and work flows.
The specification of almost 200 windows within the internal walls of the building also created challenges in terms of constructing a smooth and seamless interior that is easy to maintain to strict cleanliness standards. The windows needed to fit flush within the wall so each double-glazed vision panel is recessed within the partition wall to create a completely smooth transition between the wall and glazed surfaces. Indeed, all areas of the internal specification had to be similarly focused on cleanliness. There are no sharp edges, corners or recesses anywhere within the building and the specification for all floors, walls and ceilings creates a homogenous vinyl wrap, with welded vinyl surfaces for a seamless transition from floor to wall and wall to ceiling. The door closures also have to be cleanable to the very highest standards and the BES design team worked closely with the door manufacturer to refine the design and develop a bespoke solution. To aid co-ordination of architectural and building services design elements the integrated design team used Revit 3D modelling software to aid clash detection. AstraZeneca also made a vacant building on the campus available to the design team, allowing a full-scale model of some of the key areas to be fitted out to spec. This enabled the end users and the cleaning teams to actively consult on the physical space and proposed interior specification, so that modifications could be made. Indeed, this element of consultative design
The new building was conceived as a state-of- the-art environment to underpin staff safety, production efficiency and quality of output, while ensuring continuity of supply and high levels of availability for clinicians and end users.
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WWW.CLINICALSERVICESJOURNAL.COM NOVEMBER 2018
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