search.noResults

search.searching

dataCollection.invalidEmail
note.createNoteMessage

search.noResults

search.searching

orderForm.title

orderForm.productCode
orderForm.description
orderForm.quantity
orderForm.itemPrice
orderForm.price
orderForm.totalPrice
orderForm.deliveryDetails.billingAddress
orderForm.deliveryDetails.deliveryAddress
orderForm.noItems
t


STAFF SAFETY


An integrated approach to design


Graham Drew from cleanroom and sterile facility design and build specialist,BES,discusses the design considerations for AstraZeneca’s new production facility.


AstraZeneca’s Campus in Macclesfield is a centre for advanced manufacturing, including some of the company’s oncology products. With high levels of global demand and an extremely complex processing requirements, AstraZeneca needed to ensure that its production capabilities could keep pace with current and future demand. To facilitate this, the biopharmaceuticals giant decided some time back to invest in a new production facility to complement its existing capabilities. The new building was conceived as a state-of-the-art environment to underpin staff safety, production efficiency and quality of output, while ensuring continuity of supply and high levels of availability for clinicians and end users. BES was contracted to deliver the £30 million architectural design, building services engineering and fit out of the new facility at Macclesfield, The design and construction programme had to be aligned with the specification of advanced pharmaceutical production equipment, which was then precision-fitted within the bespoke design, and delivered within a business critical 18 month time frame.


Early engagement


As a specialist in the design and construction of cleanrooms and sterile production facilities and a long-term delivery chain partner for AstraZeneca, BES was brought in to advise on the project from concept design stage, ensuring all considerations relating to architectural design, building services engineering and buildability were factored into the design process from the earliest stages. This focus on early engagement enables the end user to leverage the full value of the cleanroom specialist’s expertise ensuring that the brief is fully interrogated so that a User Requirement Specification (URS) can be compiled and agreed.


While the aim of the new facility was to extend production capacity rather than replacing the existing production facility, the project team saw an opportunity to improve on legacy facilities in several ways. Innovations in processing equipment meant that the arrangement of the floorplate would need to change and this also provided an opportunity to consider a lean management approach to designing the layout around a more efficient production


Graham Drew, BES.


process aligned to the spatial requirements of the required equipment.


Indeed, at the outset, no firm decisions had been made regarding the exact pieces of equipment that would be specified and a full process of end user engagement was required to ascertain exactly what was needed to optimise the new facility in terms of process so that BES, the construction contractor and the equipment specialist could work together to determine the size and layout of the building required. Once critical decisions about the equipment requirements had been made, the BES team travelled to Germany to review the equipment so that spatial, loading and buildability considerations could be incorporated into the architectural design. Given the size and weight of the equipment, for example, the design team had to consider how some pieces of kit would be manoeuvred into position, which ultimately led to the decision to build the facility around apertures that would enable major elements of the equipment specification to complete the wall area by effectively plugging the space created for them. This strategy will also enable equipment to be replaced if the need should arise, helping to ensure the longevity of the building. With these initial plans agreed, BES appointed a design team to take the project from concept to detailed design, taking an office on site at AstraZeneca and permanently locating key members of the team at the Macclesfield campus for the duration of the project.


NOVEMBER 2018 WWW.CLINICALSERVICESJOURNAL.COM I 77


Page 1  |  Page 2  |  Page 3  |  Page 4  |  Page 5  |  Page 6  |  Page 7  |  Page 8  |  Page 9  |  Page 10  |  Page 11  |  Page 12  |  Page 13  |  Page 14  |  Page 15  |  Page 16  |  Page 17  |  Page 18  |  Page 19  |  Page 20  |  Page 21  |  Page 22  |  Page 23  |  Page 24  |  Page 25  |  Page 26  |  Page 27  |  Page 28  |  Page 29  |  Page 30  |  Page 31  |  Page 32  |  Page 33  |  Page 34  |  Page 35  |  Page 36  |  Page 37  |  Page 38  |  Page 39  |  Page 40  |  Page 41  |  Page 42  |  Page 43  |  Page 44  |  Page 45  |  Page 46  |  Page 47  |  Page 48  |  Page 49  |  Page 50  |  Page 51  |  Page 52  |  Page 53  |  Page 54  |  Page 55  |  Page 56  |  Page 57  |  Page 58  |  Page 59  |  Page 60  |  Page 61  |  Page 62  |  Page 63  |  Page 64  |  Page 65  |  Page 66  |  Page 67  |  Page 68  |  Page 69  |  Page 70  |  Page 71  |  Page 72  |  Page 73  |  Page 74  |  Page 75  |  Page 76  |  Page 77  |  Page 78  |  Page 79  |  Page 80  |  Page 81  |  Page 82  |  Page 83  |  Page 84  |  Page 85  |  Page 86  |  Page 87  |  Page 88