58 Get rid of glassware variability
Based on widely accepted surveys of lab practices, many aspects of manual volumetric sample preparation are subject to variability or uncertainty and can lead to imprecise concentrations and OOS results. These include glassware failure, endo- or exothermic reactions caused by environmental/glassware temperature mismatch, glassware contamination, relative percentage errors (especially with smaller flasks), labelling errors, and sample mix- ups. This list does not even account for the cost of periodic flask revalidation, which can be significant in high-volume labs.
Gravimetric sample preparation eliminates these inherent sources of process variability and the costs associated with them, resulting in more accurate, consistent sample concentrations and lower overall processing costs.
issue of accuracy without wasting valuable substance or adding rework time to a sample preparation workflow. This repeatable accuracy can all but eliminate the possibility of OOS errors arising from the often-repeated act of sample preparation.
Ensure regulatory compliance
If any lingering questions in the minds of lab operators remain over whether gravimetric sample preparation meets pharmaceutical regulations, USP 1251 should help put them to rest. The United States Pharmacopeia, or USP, has established methods for weighing both solid and solvent into a vial or container on a balance for sample preparation and dilution.
In closing, gravimetric sample preparation produces more accurate, consistent dosing for fewer OOS results. Couple this advantage with enhanced operator safety, smaller sample volumes, and time and monetary savings, and it becomes clear that gravimetric sample preparation is poised to help labs surmount the three primary challenges of modern pharmaceutical manufacturing by helping them create sustainable accuracy, productivity, and safety in their sample preparation workflows.
Safety, Accuracy and Speed: The XPR Automatic Balance
Safety is important when handling active substances, but so are accuracy and speed. Using the XPR Automatic Balance for direct gravimetric dosing reduces your exposure risk while significantly enhancing throughput.
Assure accurate results - every time
Technology available to facilitate gravimetric sample preparation varies. However, in general, powders and liquids are both delivered into small, disposable target vials positioned on an analytical or semi- micro balance to achieve a concentration specified by the user.
Spatulas and cross-contamination risk are eliminated by use of an individual dosing head for each powder storage container, enhancing operator safety. However, dosing accuracy is enhanced impressively as well, because if a specific powder is overshot either manually or automatically, the amount of diluent can be increased automatically to keep concentrations consistent. This solves the
With XPR Automatic, you can dose from an enclosed head into targets including capsules with diameters as small as six millimetres. The balance’s ability to actively monitor flow characteristics helps to improve dispensing efficiency, while the addition of automatic weight- based liquid dosing lets you achieve precise concentrations and reduce sample sizes by as much as 30%.
XPR Automatic also supports manual processes and fits easily inside your safety enclosures. Learn more about how this revolutionary balance reduces exposure risk, improves efficiency, and assures weighing accuracy now.
www.mt.com/xpr-automatic
Smart Lab Software Solutions Support Social Distancing and Remote Work
The SARS-CoV-2 pandemic has a wide range of effects on laboratories around the world. This includes not only the current high volume of requests for PCR tests for the novel coronavirus. It has challenged laboratories worldwide with respect to quickly adopting digital technologies to cope with the new norms of social distancing, remote work away from laboratory benches. These past months have proven that digitalisation is central to every interaction - in the private realm as well as in business - and has fast-tracked the acceptance of digital solutions. In fact, our everyday lives, and therefore our work in the laboratory, are certain to experience noticeable and lasting changes.
Various approaches exist for optimising laboratories for improving the use of existing assets through digital applications. In order to meet the new demands and overcome challenges in laboratories worldwide, Eppendorf offers smart lab management software solutions for laboratory management, such as the VisioNize®
Lab Suite, which enhance productivity for all routine tasks in the laboratory.
VisioNize Lab Suite is the solution for effective lab management in the areas of remote monitoring, alarm notifications, device management and task management. The service suite is continually updated and as such, it represents a sustainable investment in the laboratory of the future.
Back in 1961, Eppendorf launched the world’s first microliter system, the ‘Marburg Pipette’, thus revolutionising pipetting forever. The year 2021 marks both the 60th anniversary of this groundbreaking development and the next step Eppendorf is taking to support scientists on the way to the networked laboratory of the future.
More information online:
ilmt.co/PL/51eX 54842pr@reply-direct.com
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