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Multi-angle Light Scattering Detector for Accurate Molecular Measurement
Over the past four decades, light scattering has become widely used for molecular weight and size measurement of proteins and polymers. However, the most recent and ever more demanding characterisation needs require to overcome the limitations of the various traditional technologies in light scattering detection.
The Tosoh LenS3® Multi-Angle Light Scattering (MALS) detector features an elongated flow path geometry that maximises scattered light collection,
while the non-refractive material of the chamber eliminates noise from stray light. The advanced optical design also provides exceptional signal-to-noise at the crucial extreme angles for molecular weight and size measurements.
The resulting enhanced capabilities and unprecedented sensitivity of the LenS3 MALS detector provide a direct and accurate measurement of molecular weight, even for oligomers and low dn/dc samples. Moreover, the range of radius of gyration (Rg) determination by light scattering is extended down to a few nanometers for the very first time.
Read Tosoh Bioscience’s latest whitepaper here:
ilmt.co/PL/0ddQ
A new technical note delivers also more detailed information on the MALS detector:
ilmt.co/PL/1ddW More information online:
ilmt.co/PL/yJJo
55216pr@reply-direct.com
Versatile Multi Detector GPC/SEC System
The new HK Series Multi Detector GPC/SEC System from Testa Analytical Solutions eK combines high-performance chromatographic detector technologies and powerful, yet easy to use software to unlock the secrets of even the most complex synthetic polymers and natural macromolecules.
Gel Permeation Chromatography/Size Exclusion Chromatography (GPC/SEC) is widely accepted as the analytical technique of choice to characterise polymers and separate mixtures into fractions including polymer, oligomer, monomer and any non-polymeric additives. GPC/SEC is also the ‘go-to’ technique for characterising the molecular weight distribution of polymers.
However, increasingly widespread use of more complex synthetic polymers and macromolecules of natural origin such as proteins and peptides, requires advanced characterisation technologies to allow researcher gain a thorough understanding of their shape, structure and related physical properties. GPC/SEC systems combining measurements from multiple detectors not only provides increased amounts of data, but also information, which is available due to the combination of different detectors that would not be obtainable using the individual detectors separately.
With the new HK Series Multi-Detector GPC/SEC System, you can choose from a wide combination of detectors including differential refractive index (DRI), Multiple Angle Light Scattering (MALS), viscometry, ultraviolet (UV) and flow measurement.
This versatile system can be used to analyse a wide range of polymers, regardless of molecular weight range or solvent. The combination of these different sensitive detectors can deliver accurate, absolute molecular weight, size and distribution information as well as useful data to derive fundamental parameters such as radius of gyration, concentration, intrinsic viscosity, specific refractive index increment (dn/dc) and second virial coefficient.
Each detector has independent temperature control to ensure that high levels of precision and reproducibility can easily be achieved from one day to the next. This powerful multi-detector GPC/SEC platform is supported by a powerful software suite that combines highly intuitive operation with all the necessary tools to generate and present results from the collected raw data.
More information online:
ilmt.co/PL/kYrW 55027pr@reply-direct.com
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